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Biomarker Discovered That Could Help Identify High-Risk COVID-19 Patients
Researchers have discovered a biomarker that could assist in the early identification of people at high risk of developing severe COVID-19.
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Bacterial Signature For Infected Teeth and Gums
Researchers have found that a characteristic shift in bacterial community composition and function marks progression from a healthy mouth to periodontal disease.
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“Switchable” Proteins Used for Biomedical Imaging
Switchable label proteins can change their state, for example to a signal that can be read out, or upon illumination with different colors of light. Researchers at Helmholtz Munich describe their latest work in this space.
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Chronic Stress Speeds Up Life's Clock, But Not for Everyone
Scientists in recent years have developed “epigenetic clocks” to measure biological age. In a new study, researchers used one such clock to ask two questions: How much does chronic stress accelerate that biological clock? And are there ways to slow it down and extend a healthy lifespan?
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The Molecular Structure of Black Widow Spider Venom Is Revealed
A new study has taken a world-first molecular look at the structure of black widow venom, which contains a subclass of neurotoxins called latrotoxins.
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Four-Stranded DNA Structures Found To Play a Role in Aging Disease
Researchers have observed a protein called Cockayne Syndrome B (CSB) preferentially interacting with a special form of four-stranded DNA.
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First Single-Cell Atlas of the Human Eye Constructed
The cell-by-cell atlas will help in the study of eye disorders and development of cell therapy to replace damaged eye tissue.
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How Some Tissues Can “Breathe” Without Oxygen
Research shows that when cells are deprived of oxygen, another molecule called fumarate can step in and serve as a terminal electron acceptor to enable mitochondrial function in this environment.
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Tackling Lassa Virus Infection With Structural Clues
Lassa fever is listed as a significant public health threat with high epidemic potential and no effective countermeasures. Researchers have now used structural biology to detail nine structures of the Lassa viral polymerase in different functional configurations.
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Novel Drug Class With Activity Against SARS-CoV-2 Identified
Researchers report a new candidate ribonucleoside analog, 4’-fluorouridine, that has potent antiviral activity against SARS-CoV-2 and other respiratory RNA viruses in cell culture, human organoids and different animal models when administered once daily.
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