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FDA-approved Drugs Reverse Aging in Nematodes
Researchers collaborated to derive a transcriptomic signature of aging, which they confirmed using large transcriptomic databases. They discovered that aging in nematodes is partially programmed and can be therapeutically reversed by a number of FDA-approved drugs.
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Preterm Birth Biomarkers Detected in 3D-printed Device
A 3D-printed microchip device can sensitively detect three serum biomarkers of pre-term birth. The device, which utilizes electrophoresis, is easy to use and has the potential to better inform doctors and improve outcomes.
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World’s Smartest Computer Creates Model of Complex Protein Machinery
A team of researchers used the 200-petaflop IBM AC922 Summit system, the world's smartest and most powerful supercomputer, to develop an integrative model of the transcription preinitiation complex (PIC), a complex of proteins vital to gene expression.
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Bonus Discovery Could Help Environmental Cleanup
In solving a scientific mystery, researchers also discovered a new avenue for clearing toxins from water, including wastewater produced by hydraulic fracturing.
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What Next After GWAS?
Genome-wide association studies (GWAS) look at large populations to find genes that contribute to common, multi-gene traits like height or obesity. These comprehensive studies frequently turn up large numbers of tiny genetic variations that occur more often in people who are tall, obese, etc. So which genes should scientists investigate further?
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Mapping Influenza's Armory in Real-time
High-speed microscopy has been used to investigate the native structure and conformational dynamics of hemagglutinin in influenza A.
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Casting a Spotlight on Cancer Metabolism With Bioluminescence
Scientists have invented a new way to quantify - in real-time - glucose metabolism of cancerous tumors by making them bioluminesce.
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Wave Goodbye to Weights as We Know Them
Following the General Conference on Weights and Measures in November 2018, perhaps one of the most significant revisions to the International System of Units (the SI) since its inception was agreed. Today, on World Metrology Day, it is being put into action.
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Revealing Dangerous Pathogen's Door Key
Researchers have revealed the 3D molecular architecture of the Type IV secretion system (T4SS), used by many dangerous bacteria to infect human cells, from Legionella pneumophila with unprecedented details.
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Timing Is Key in Cell Protein Production
Scientists at the University of Sheffield have discovered how genes create proteins in research which could aid the development of treatments for human diseases.
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