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The Key to a Good Night’s Sleep?
A team of researchers has now created 3D maps of MT1 and MT2 melatonin receptors revealing the structural basis of the selectivity of each receptor subtype. They intend to use this structural information to develop novel drugs capable of tackling sleep disorders.
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Cryo-EM Material Advancements May Aid Medical Research
With new substrates, researchers have the potential to get all their data on the samples in as little as an hour, as opposed to what would currently take days.
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Blood Test Indicates Alzheimer's Drug Effect on Nerve Cell Loss
A new study confirms that a simple blood test can reveal whether there is accelerating nerve cell damage in the brain. The researchers analyzed neurofilament light protein in blood samples from patients with Alzheimer’s disease.
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How a Finch Keeps Its Head of Many Colors
The Gouldian Finch has maintained three distinct colour types for thousands of generations – finches with red heads, black heads and yellow heads – something that is extremely rare. Now, scientists have discovered the underlying mechanism that allows this to happen.
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Forget the “Fountain of Youth”, Longevity Lies in a Gene
Researchers have uncovered more evidence that the key to longevity resides in a gene, SIRT6.
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Interrogation of Single Cells Taken One Step Further With ECCITE-Seq
A new technique called ECCITE-seq allows researchers to perform high-throughput measurements of multiple modalities of information from single cells.
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Diversifying the Natural Building Blocks of Life
Using EBX reagents, researchers have converted the C-terminal carboxylic acid of peptides into a carbon-carbon triple bond - an alkyne (in chemical jargon a "decarboxylative alkynylation"). The alkyne moiety is a very valuable functional group that can be used to further modify the peptides.
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How Cells Keep DNA Tangle-free
A process that cells use to unravel knotted strands of DNA - resembling a method used to control climbing ropes - has been uncovered by scientists.
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High-risk Genes for Schizophrenia Identified
Using a unique computational "framework" they developed, a team of scientist cyber-sleuths has identified 104 high-risk genes for schizophrenia.
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Protein Structure Predictions With Deep-learning
Scientists have used a form of artificial intelligence known as deep learning to predict the 3D structure of effectively any protein based on its amino acid sequence.
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