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Cell Atlas of the Aging Lung
Aging promotes lung function decline and increases susceptibility to diseases of the respiratory tract. In order to understand these effects in detail, researchers have analyzed the aging process in the lung at single-cell level, using AI approaches.
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Flipping the View: Microscope Could Help Gauge Drug Properties
A new type of microscope, based on concepts of phase-contrast microscopy, may give doctors a better idea of how safely and effectively a medication will perform in the body.
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Unraveling DNA Replication Mysteries
DNA replication is a complex process in which a helicase ring separates the DNA molecule's two entwined and encoded strands, allowing each to precisely reproduce its missing half. Researchers have discovered how the helicase--a donut-shaped enzyme composed of six identical proteins--is able to thread just one of the strands when they are bound together. Now, researchers have solved the mystery.
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Researchers "Bait" Proteins Behind Neurodegeneration
A single misbehaving protein – called TDP-43 – is behind 97 percent of amyotrophic lateral sclerosis (ALS) cases and 45 percent of frontotemporal dementia diagnoses. It also is found in 80 percent of chronic traumatic encephalopathy and 60 percent of Alzheimer’s disease cases. Now, researchers have found a way to trap TDP-43 so it doesn’t form toxic clumps that can cause neurodegeneration.
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Structure of the Human Cannabinoid Receptor CB2 Solved
A Chinese research team joined forces with Russian and U.S. biologists to obtain the crystal structure of the human type 2 cannabinoid receptor. Their findings will help develop drugs against inflammatory, neurodegenerative, and other diseases.
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Ramping Up Proteasomes in Muscle and Liver Cells
Hormones and conditions that raise cAMP rapidly enhance the cells' capacity to eliminate damaged and preexistent regulatory proteins.
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Gene May Predict the Development of Pancreatic Cancer
Mayo Clinic researchers have identified a gene called "UCP-1" that may predict the development of pancreatic cancer in people with Type 2 diabetes.
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Potential Therapeutic Target for Colon Cancer
Researchers have pinpointed a set of enzymes involved in tumor growth that could be targeted to prevent or treat colon cancer.
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Protein “Switch” May Halt Progression of Sepsis
Scientists have discovered a new protein "switch" that could stop the progression of blood-poisoning, or sepsis, and increase the chances of surviving the life-threatening disease.
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Skin Molecules Are Mapped in the Proteomic Skin Atlas
Researchers from the University of Copenhagen have studied large amounts of data from tissue samples of the skin to map its molecules and their functions.
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