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Receptor Blueprint Helps Design Osteoporosis Drugs
Researchers at the University of Zurich have determined the three-dimensional structure of a receptor that controls the release of calcium from bones. The receptor is now one of the main candidates for developing new drugs to treat osteoporosis.
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Fighting the Good Fight
Blocking an important enzyme in staphylococcal metabolism in a targeted manner would allow the pathogens to be starved.
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Membrane Proteins Ejected Directly from Cell Membrane to Mass Spec
A new approach to analyzing cell membrane proteins in situ could revolutionize the way in which we study diseases, such as cancer, metabolic and heart diseases.
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Leukemia Stem Cells Rely on Amino Acids for Survival
Clinically relevant eradication of leukemia stem cells could be achieved with drugs that target their metabolic vulnerabilities.
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Ketone Shuttle Coordinates Response to Liver Fibrosis
A metabolite shuttle, or dialogue, provides a connection between hepatocyte and macrophage cell types in the liver and helps protect against tissue fibrosis.
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Should You Eat a Low-gluten Diet?
When healthy people eat a reduced-gluten and fiber-rich diet they experience less intestinal discomfort and bloating but this is more likely due to a change in composition of dietary fibers than gluten itself.
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He or She? Remains Tell the Whole Tooth
Researchers have come up with a new way to estimate the biological sex of human skeletal remains based on protein traces from teeth.
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Anti-Aging Protein Protects the Brain from the Immune System
The choroid plexus is a complex network of cells that produce cerebrospinal fluid, and form an important barrier between the CNS and the blood. A new study has set out to discover why it also contains vastly higher levels of the anti-aging protein klotho that any other brain region.
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Saliva-based Biomarkers and Algorithm Could Aid Autism Diagnosis
A saliva-based biomarker panel and algorithm could help fast-track the identification of children who are suspected of having autism spectrum disorder.
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Promising Marker for Immune Invasion and Immunotherapy Failure
An extracellular matrix gene signature has been identified which is associated with response to immunotherapy, and provides a hypothesis about why some people don't respond.
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