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Putting New Facility through its Paces Reveals Killer Details
The results of the first scientific experiments at Europe's new X-ray laser European XFEL reveals a previously unknown structure of an enzyme responsible for antibiotic resistance.
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Unexpected Enzyme Structure Holds Handy Properties
Unexpected enzyme structure holds promise for removal of greenhouse gases from the atmosphere to turn them into useful carbon-containing compounds.
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Enzyme Evolution Wins Nobel Prize for Chemistry
The power of evolution is revealed through the diversity of life. The 2018 Nobel Laureates in Chemistry have taken control of evolution and used it for purposes that bring the greatest benefit to humankind. Enzymes produced through directed evolution are used to manufacture everything from biofuels to pharmaceuticals. Antibodies evolved using a method called phage display can combat autoimmune diseases and in some cases cure metastatic cancer.
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Stroke Treatment Target Revealed
A novel hybrid approach has revealed a 3-D structure of a protein fragment that could serve as a drug target in treating stroke patients.
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Diet Impacts Breast Microbiome
The breast gland also has a microbiome, and like the gut microbiome, it too can be affected by diet.
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How the Cell Protects DNA from Degradation
Researchers have succeeded in depleting AND-1, a key protein for DNA replication, by using a recently developed conditional protein degradation system. Consequently, they were able to gain unprecedented access to the mechanism behind how AND-1 works during DNA replication and cell proliferation in vertebrate cells.
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The Proteins Controlled By Light
Researchers developed fluorescent proteins that can be controlled by orange and green light. These proteins will help to study processes in living cells. The work was supported by Russian Science Foundation (RSF) grant, and the results were published in Nature Methods.
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Green Algae Stole to Survive
Green algae are expected to survive climate change, thanks to hardy genes they stole from bacteria.
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Killer Protein Structure Insights
Insights have been gained into the structure of the nomadic, killer protein Bax, responsible for programmed cell death.
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Two-Pronged Approach Reveals Drug Combination for Lung Cancer
Moffitt Cancer Center researchers are combining the large-scale study of proteins (proteomics) with a new data integration method to identify a previously unknown mechanism for midostaurin in lung cancer. Midostaurin is a drug approved by the FDA for the treatment of acute myeloid leukemia and advanced systemic mastocytosis.
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