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A human torso and head outline with organs and lymph systems visible.
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Innovative Platform for Targeting Protein Stability in Disease Treatment

Using a newly created platform, researchers have interrogated the entire human proteome for "effector" proteins, which can influence the stability of other proteins via induced proximity. The scientists were able to identify many new effectors with possible therapeutic uses.
Histology of ovaries from healthy mice vs. mice without Usp7 gene.
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Researchers Uncover Protein Networks in Female Mouse Reproduction

Scientists have found that while a protein called FOXL2 plays a role in embryonic development, it regulates the activity of many more genes after birth.
Accumulation of "junk proteins": normal cells (left) and cells subjected to the effect of the toxic arginine-rich protein (right). In the latter, ribosomal proteins (green fluorescent) and the size of nucleoli (red) are increased.
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“Junk Proteins” Associated With Cause of Aging and ALS Progression

CNIO researchers provide a new hypothesis to understand the origin of amyotrophic lateral sclerosis, or ALS. It would be triggered by a similar problem to that occurring in a group of rare diseases called ribosomopathies.
Prototype of the ExoArc system.
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New Device Rapidly Isolates Blood Plasma for Diagnostics and Precision Medicine

Scientists have developed a coin-sized chip that can directly isolate blood plasma from a tube of blood in just 30 minutes, which is more convenient and user-friendly as compared to the current gold standard, multi-step centrifugation process.
An astronaut on the moon.
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Microgravity Triggers Change in Human Gene Expression Rhythms

Simulated effects of microgravity, created by 60 days of constant bed rest, severely disrupts rhythmic gene expression in humans, according to a new study from the University of Surrey.
A tick.
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Protein Found in Human Sweat May Protect Against Lyme Disease

Human sweat contains a protein that may protect against Lyme disease, according to a study. About one-third of the population carries a genetic variant of this protein that is associated with Lyme disease in genome-wide association studies.
A bar chart on top of a mountain scene.
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New Method Identifies Extremophiles Using Protein Fragments

Perfectly adapted microorganisms live in extreme environments from deep-sea trenches to mountaintops. Learning more about how these extremophiles survive in hostile conditions could inform scientists about life on Earth.
The path of the Candidalysis toxin is mapped in yellow.
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Function of Candida albicans Toxin’s Unique Protein Arrangement Uncovered

New insights into the unique protein arrangement of the Candida albicans toxin Candidalysin show promise for new treatments.
Cancer cells.
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Targeting Cancer-Fueling Proteins Shows Potential for Treating Aggressive Leukaemia

Researchers have found a new way to potentially treat one of the most common forms of acute lymphoblastic leukaemia. The study was able to kill leukaemia cells in the lab and stop cancer cells from growing.
Cell bio.
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Your Cells Know the Importance of Recycling

Researchers uncovered the mechanistic details behind how several proteins interact to help cells recognize and remove damaged mitochondria. This mechanism may have relevance for developing drugs to treat Parkinson’s disease.
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