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5-Minute EEGs Could Help Researchers Peer Inside the Parkinson's Brain
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5-Minute EEGs Could Help Researchers Peer Inside the Parkinson's Brain

5-Minute EEGs Could Help Researchers Peer Inside the Parkinson's Brain
News

5-Minute EEGs Could Help Researchers Peer Inside the Parkinson's Brain

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What causes the characteristic slowing of movement in patients with Parkinson's disease? Electrical oscillations of nerve cells deep inside the brain and the cortex are pathologically coupled with each other. Researchers know this from recordings taken from the brains of Parkinson's patients during surgery to fit a brain pacemaker.

But is it possible to detect this coupling if the electrical nerve activity is only derived from the patient's scalp, by electroencephalogram (EEG)? Doctoral researcher Ruxue Gong investigated this with a team of scientists led by Professor Joseph Claßen, Director of the Department of Neurology at Leipzig University Hospital, and Professor Thomas Knösche from the MPI for Human Cognitive and Brain Sciences.

In the EEG measurements, which lasted just five minutes, the researchers really did find such couplings in Parkinson's patients. Compared to healthy subjects, these couplings are enhanced in brain regions that serve to control movement. The breaking of coupling between oscillations at different locations could be particularly important for therapeutic approaches to address Parkinson's symptoms. "Using external electrical or magnetic stimulation, we hope that in future it will be possible to correct the coupled electrical oscillations in Parkinson's patients without the need for surgery," said Claßen. "With our mathematical modeling, we want to find out what characteristics such novel therapies would need to ensure their success. These new findings may represent an important building block in this respect," said Knösche.

Moreover, pathological coupling was also detected in an individual area of the cerebral cortex which is only slightly involved in motor control. "Perhaps the cognitive disorders that exist in some Parkinson's patients have a common cause with motor disorders," said Claßen. Future studies will investigate this thesis further.

Reference: Gong R, Wegscheider M, Mühlberg C, et al. Spatiotemporal features of β-γ phase-amplitude coupling in Parkinson’s disease derived from scalp EEG. Brain. 2020. doi:10.1093/brain/awaa400

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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