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Gut Microbes May Have Helped Fuel the Evolution of Large Brains
Researchers show gut microbes may have fueled brain evolution by optimizing energy use. Experiments revealed that microbes in large-brained primates like humans and squirrel monkeys promoted higher energy expenditure.
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Predicting the Effectiveness of Spinal Cord Stimulation
Spinal cord stimulation is often a last resort for those with intractable chronic pain. A new 10-minute brain scan gives doctors a much-needed biomarker to discuss with patients considering spinal cord stimulation.
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Study Captures the Aging Process of Muscles at the Cellular Level
As muscles age, their cells lose the ability to regenerate and heal after injury. Researchers have created the most comprehensive picture yet of this process.
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Researchers Identify Which Proteins Open and Close Stomata in Response to Drought
Researchers have unraveled the cellular mechanisms behind stomata opening and closing.
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Six-Gene Pattern Predicts Drug Success for Multiple Myeloma Patients
Researchers identified a six-gene pattern predicting venetoclax response in multiple myeloma. This genetic insight allows for personalized treatments, improving patient outcomes.
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Bile Composition Changes To Help Combat Intestinal Infections
Brigham and Women’s researchers uncover bile’s dynamic role in intestinal infection defense, revealing compositional changes that enhance gut protection. Using a mouse model, they identified over 800 bile metabolites altered by pathogens.
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How Sea Anemones Maintain Shape While Regenerating
Researchers discovered that starlet sea anemones reshape their entire bodies during regeneration to maintain their original proportions. Using spatial transcriptomics, the team identified enzymes active throughout the body that realign tissues.
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Scientists Uncover Key Stress Pathway Driving Migraines
UT Health San Antonio researchers discovered that stress-induced migraines are driven by PACAP38 binding to MrgprB2 on mast cells, leading to inflammatory responses and trigeminal sensitization.
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How Bacteria Outwit Antibiotics by Altering Ribosomal Structures
Researchers uncovered a novel bacterial resistance strategy where E. coli modifies ribosomal structures to evade antibiotics like streptomycin and kasugamycin. Using nanopore sequencing, the study revealed ribosomal changes that prevent effective dru
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Protein Mobility May Be a Key Driver of Decreased Cellular Function in Chronic Disease
A study identifies "proteolethargy," reduced protein mobility caused by oxidative stress, as a unifying mechanism in chronic diseases. The findings suggest that impaired protein movement disrupts cellular functions.
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