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Alzheimer's Pathology: Inflammation Leads to Devastation

News   Aug 30, 2017 | Original Story from UNC Healthcare and UNC School of Medicine

Alzheimer's Pathology: Inflammation induces neuritic beading and accumulation of abnormal tau

Neurons treated with Alzheimer's-associated proteins exhibit drastic calcium increases (blue, green, yellow, red to white), and the cells form tau-filled beaded structures (shown with arrows) identical to neurons seen in Alzheimer's patients. Credit: Cohen Lab, UNC School of Medicine



Alzheimer's Protein Segment Plays the Hero in the Mouse Brain


The amyloid precursor protein has always been vilified as a major cause of Alzheimer’s disease. However, a recent has shown how it has an extended role in brain signaling that can prevent the development of Alzheimer’s disease in mice.


Single Gut Bacteria Enterotype Associates Multiple Types of Inflammatory Bowel Disease


Researchers who sequenced the fecal samples of over 3,000 healthy volunteers recently described the so-called B2 enterotype, which is deficient in some anti-inflammatory bacteria. Today, they published more data, showing the high prevalence of this particular enterotype across multiple disease diagnoses.


Antioxidant Overwhelmed by Tau in the Alzheimer's Brain


New research may explain why an antioxidant that protects the brain is also associated with deterioration in areas susceptible to Alzheimer’s disease. The antioxidant, superoxide dismutase or SOD1, improves cognition, but an Iowa State University research team found SOD1’s protective benefits dramatically weaken when levels of tau proteins – a hallmark of Alzheimer’s disease – increase.



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