BAC and Octapharma Extend Recombinant Factor IX Collaboration for Clinical and Commercial Scale Production, and Initiate a Further Blood Disorder Programme
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Octapharma produces FIX for the treatment of bleeding in Haemophilia B. The licence agreement follows on from successful completion of feasibility studies. Concurrently, the companies have embarked on a new discovery programme under which BAC will develop a CaptureSelect affinity ligand for the purification of recombinant human granulocyte-colony stimulating factor (G-CSF), which has applications in oncology and haematology.
Under the terms of the FIX agreement Octapharma will have licence to use BAC’s anti-FIX ligand for the purification of FIX from mammalian cell culture. Under the terms of the G-CSF agreement BAC will perform ligand discovery and development to provide an anti-G-CSF ligand, which will then undergo feasibility studies at Octapharma.
Factor IX is an essential product for the prophylaxis and treatment of bleeding in Haemophilia B, an X-linked recessive blood disorder that affects around 1 in 30,000 men. Octapharma currently markets a plasma-derived FIX product and is now progressing its recombinant FIX project. G-CSF is a hormone that stimulates bone marrow to produce white blood cells and stem cells, and has therapeutic uses in oncology and haematology.
