Cognitive & brain reserves have long-term protective effect against cognitive decline in MS, researchers find
News May 01, 2014
Study confirms prior research and shows that effects persist for years
Multiple sclerosis researchers have found that brain reserve and cognitive reserve confer a long-term protective effect against cognitive decline.
James Sumowski, PhD, lead author of the article, and John DeLuca, PhD, are at Kessler Foundation. Co-authors are from the Manhattan Memory Center, New York, NY, the San Raffaele Scientific Institute, Milan, Italy, and the University of Belgrade, Serbia. Neurology is the official journal of the American Academy of Neurology. Dr. Sumowski presented these findings at the AAN 2014 conference in Philadelphia.
"Our research aims to answer these questions," explained Dr. DeLuca. "Why do some people with MS experience disabling symptoms of cognitive decline, while others maintain their cognitive abilities despite neuroimaging evidence of significant disease progression? Can the theories of brain reserve and cognitive reserve explain this dichotomy? Can we identify predictors of cognitive decline?"
In this study, memory, cognitive efficiency, vocabulary (a measure of intellectual enrichment/cognitive reserve), brain volume (a measure of brain reserve), and disease progression on MRI, were evaluated in 40 patients with MS at baseline and at 4.5-year followup. After controlling for disease progression, scientists looked at the impact of brain volume and intellectual enrichment on cognitive decline.
Results supported the protective effects of brain reserve and cognitive reserve," noted Dr. Sumowski. "Patients with greater intellectual enrichment experienced lesser degrees of cognitive decline. Those with greater brain reserve showed a protective effect for cognitive efficiency. This study not only confirms these protective effects of brain and cognitive reserve, it shows that these beneficial effects persist for years."
Note: Material may have been edited for length and content. For further information, please contact the cited source.
J. F. Sumowski, M. A. Rocca, V. M. Leavitt, J. Dackovic, S. Mesaros, J. Drulovic, J. DeLuca, M. Filippi. Brain reserve and cognitive reserve protect against cognitive decline over 4.5 years in MS. Neurology, Published Online April 18 2014. doi: 10.1212/WNL.0000000000000433
Avatar Therapy Successfully Treats Schizophrenic Patients Suffering from Auditory HallucinationsNews
Researchers found that avatar therapy was more effective at reducing hallucinations than counseling.READ MORE
Abnormal Prion Protein Found in the Skin of Patients That Died of CJDNews
Scientists have detected abnormal prion protein in the skin of nearly two dozen people who died from Creutzfeldt-Jakob disease (CJD).READ MORE
Whole-Brain Map of Memory Circuits Constructed from Human DataNews
The work elucidates the way different regions of the brain communicate during cognitive processes like memory formation.READ MORE