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The Role of PKC in Synaptic Plasticity

News   Jul 17, 2018 | Original Story from Max Planck Florida Institute for Neuroscience

Convergence of Synaptic Signals is Mediated by a Protein Critical for Learning and Memory

Model of integration of TrkB and calcium signals to induce PKCα activation in paired and unpaired subthreshold stimulations. A subthreshold stimulus that was unable to induce plasticity was given alone (unpaired) or after a nearby plasticity-inducing stimulation (paired). Unpaired, the stimulus could not activate PKCa or induce plasticity. However, when paired with recent plasticity in a nearby spine, which induces a long-lasting, spreading TrkB activity, this same subthreshold stimulus led to PKCa activation and plasticity. Credit: Max Planck Florida Institute for Neuroscience



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