We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement

Detailed Mitochondrial Phenotyping by High Resolution Metabolomics


Want a FREE PDF version of this news story?

Complete the form below and we will email you a PDF version of "Detailed Mitochondrial Phenotyping by High Resolution Metabolomics"

Listen with
Speechify
0:00
Register for free to listen to this article
Thank you. Listen to this article using the player above.
Read time:
 

Abstract
Mitochondrial phenotype is complex and difficult to define at the level of individual cell types. Newer metabolic profiling methods provide information on dozens of metabolic pathways from a relatively small sample. This pilot study used "top-down" metabolic profiling to determine the spectrum of metabolites present in liver mitochondria. High resolution mass spectral analyses and multivariate statistical tests provided global metabolic information about mitochondria and showed that liver mitochondria possess a significant phenotype based on gender and genotype. The data also show that mitochondria contain a large number of unidentified chemicals.

The article is published online in PLoS ONE and is free to access.

Advertisement