Early results indicate potential for focused ultrasound to treat OCD
News Dec 09, 2014
Important Step Toward A Non-Invasive Procedure for Psychiatric Disorders
A recently published report in the Journal of Molecular Psychiatry supports the potential of focused ultrasound to treat certain patients with obsessive-compulsive disorder (OCD).
In a study of feasibility, safety and preliminary efficacy, four patients with disabling OCD unresponsive to medical therapy were treated by ablating small targets deep in the brain (anterior internal capsule) using the InSightec ExAblate Neuro MR-guided focused ultrasound system. This proof-of-concept study is being conducted with 12 patients by Jin Woo Chang, MD, PhD, at the Yonsei University Medical Center in Seoul, Korea. The results of the first four patients with six months follow-up were published.
All four patients had the targeted areas of the brain successfully ablated. The procedures were accomplished without complications or side effects and resulted in gradual improvement in obsessive-compulsive thoughts and behaviors as well as showing the nearly immediate and sustained improvement in depression and anxiety over six months.
"There is a need for non-invasive treatment options for patients with OCD that cannot be managed through medication," says Dr. Chang. "Using focused ultrasound, we were able to reduce the symptoms for these patients and help them get some of their life back without the risks or complications of the more invasive surgical approaches that are currently available."
"If these initial results are confirmed in the remaining eight patients in this study as well as in a larger pivotal trial of safety and efficacy, focused ultrasound could emerge as an alternative to surgery for improving quality of life in a cost-effective manner for patients with OCD," said Foundation Chairman Neal F. Kassell, MD. "This could also serve as the predicate for non-invasive therapy for other psychiatric disorders."
Dr. Chang plans to start a study using focused ultrasound to treat depression in 2015.
Current Treatment for OCD
OCD is a psychiatric disorder characterized by recurring anxiety-provoking thoughts (obsessions) that are alleviated only by ritualistic actions (compulsions) such as hand washing. OCD symptoms can be overwhelming and result in severe impairment and dysfunction. Patients also have a high risk for depression, with two-thirds of OCD patients developing major depression.
Although a large portion of OCD patients improve with drug therapy, some patients have debilitating symptoms that are resistant to treatment. For these patients, psychosurgery can be performed to destroy (ablate) a targeted region of the brain (anterior internal capsule) associated with the disorder. The currently available ablative approaches are invasive or involve radiation:
- ♦ Radiofrequency ablation requires drilling into the skull and inserting a probe through the brain.
- ♦ Stereotactic radiosurgery takes months to achieve an effect and may be associated with side effects of radiation.
- ♦ Deep brain stimulation has been used as a reversible and adjustable alternative to ablation, but it involves the risks and complications of surgery to implant the system and additional operations for battery changes.
Potential of Focused Ultrasound for OCD
Focused ultrasound has the potential to be a completely non-invasive approach for treating patients whose OCD is resistant to medical therapy. The target is an area of the brain that is easily reached and relatively small. If the positive results of Dr. Chang's proof-of-concept study are confirmed, then a larger pivotal study would be warranted to assess the definitive safety, effectiveness, and long-term durability of focused ultrasound to treat OCD.
Note: Material may have been edited for length and content. For further information, please contact the cited source.
H.H. Jung, S.J. Kim, D. Roh, J.G. Chang, W.S. Chang, E.J. Kweon, C.-H. Kim, J.W. Chang. Bilateral thermal capsulotomy with MR-guided focused ultrasound for patients with treatment-refractory obsessive-compulsive disorder: a proof-of-concept study. Molecular Psychiatry, Published November 25 2014. doi: 10.1038/mp.2014.154
Abnormal Prion Protein Found in the Skin of Patients That Died of CJDNews
Scientists have detected abnormal prion protein in the skin of nearly two dozen people who died from Creutzfeldt-Jakob disease (CJD).READ MORE
Whole-Brain Map of Memory Circuits Constructed from Human DataNews
The work elucidates the way different regions of the brain communicate during cognitive processes like memory formation.READ MORE
Long-Term Negative Physical and Mental Health Effects Associated With Disordered EatingNews
Findings from large twin study show disordered eating among 24-year-old women and men was an indicator of higher body weight, larger waist circumference, and lower psychological well-being ten years later.READ MORE