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Electron Microscopy Shows an Important Brain Receptor's "Venus Flytrap" in Action

News   Jun 18, 2020 | Original story from the University of Southern California, Dornsife

 
Electron Microscopy Shows an Important Brain Receptor's "Venus Flytrap" in Action

In this artist's depiction, cryo-EM structures of GABAB captured in four different conformations along its activation transition appear on a neuronal synapse (background) while the structure of the GABAB receptor in the active state with agonist (orange spheres) bound in GB1 (blue) and a PAM (magenta spheres) bound on the transmembrane interface between GB1 and GB2 (yellow) appears in close-up. Credit: Illustration by Yekaterina Kadyshevskaya/Bridge Institute at the USC Michelson Center for Convergent Bioscience

 
 
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