Experimental cancer drug restores memory in mouse model of Alzheimer’s
News Apr 01, 2015
Memory and as well as connections between brain cells were restored in mice with a model of Alzheimer’s given an experimental cancer drug, Yale School of Medicine researchers reported in the journal Annals of Neurology.
The drug, AZD05030, developed by Astra Zeneca proved disappointing in treating solid tumors but appears to block damage triggered during the formation of amyloid-beta plaques, a hallmark of Alzheimer’s disease. The new study, funded by an innovative National Institutes of Health (NIH) program to test failed drugs on different diseases, has led to the launch of human trials to test the efficacy of AZD05030 in Alzheimer’s patients.
“With this treatment, cells under bombardment by beta amyloid plaques show restored synaptic connections and reduced inflammation, and the animal’s memory, which was lost during the course of the disease, comes back,” said Stephen M. Strittmatter, the Vincent Coates Professor of Neurology and senior author of the study.
In the last five years, scientists have developed a more complete understanding of the complex chain of events that leads to Alzheimer’s disease. The new drug blocks one of those molecular steps, activation of the enzyme FYN, which leads to the loss of synaptic connections between brain cells. Several other steps in the disease process have the potential to be targets for new drugs, Strittmatter said.
“The speed with which this compound moved to human trials validates our New Therapeutic Uses program model and serves our mission to deliver more treatments to more patients more quickly,” said Dr. Christopher P. Austin, director of NIH’s National Center for Advancing Translational Sciences (NCATS), which funded the work.
Note: Material may have been edited for length and content. For further information, please contact the cited source.
Adam C. Kaufman, Santiago V. Salazar, Laura T. Haas, Jinhee Yang, Mikhail A. Kostylev, Amanda T. Jeng, Sophie A. Robinson, Erik C. Gunther, Christopher H. van Dyck, Haakon B. Nygaard and Stephen M. Strittmatter. Fyn inhibition rescues established memory and synapse loss in Alzheimer mice. Annals of Neurology, Published Online March 21 2015. doi: 10.1002/ana.24394
The Mouse Brain Can Prioritize Hunger by Suppressing Pain When Survival is at StakeNews
Researchers show that pain and hunger interact in complex ways in mice: extreme hunger suppresses less-urgent inflammatory pain, so that the mice are willing to go find food, but leaves them able to feel and react to more life-and-death kinds of pain.READ MORE
Comments | 0 ADD COMMENT
International Conference on Neuroimmunology, Neurological disorders and Neurogenetics
Sep 26 - Sep 27, 2018