Gamma-ray irradiation improves safety of cell therapy for Parkinson's disease
News Jun 24, 2016
Replacing dopamine-producing cells in the brain represents a promising therapeutic approach in Parkinson's disease, and a new study shows how post-transplantation gamma-ray irradiation can reduce the risk of tumor formation.
The study, in which human induced pluripotent stem (iPS) cell-derived neural progenitor cells were grafted into rat brains, is published in Stem Cells and Development.
Mitsuko Katsukawa and coauthors from Kyoto University and Kyoto University Graduate School of Medicine, Japan, describe the fail-safe strategy they developed to prevent immature or undifferentiated cells in the therapeutic graft from forming tumors, while allowing the desired cells to survive.
These results will contribute to improved safety of cell replacement therapy using human iPS cells for Parkinson's disease, conclude the researchers.
"While the world waits with bated breath to see whether the use of iPS cells in humans will proceed safely, this is the first attempt to use radiation to mitigate the risk of tumor formation after stem cell transplantation," says Editor-in-Chief Graham C. Parker, PhD, The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI.
Note: Material may have been edited for length and content. For further information, please contact the cited source.
Mitsuko K et al. Fail-Safe Therapy by Gamma-Ray Irradiation Against Tumor Formation by Human-Induced Pluripotent Stem Cell-Derived Neural Progenitors. Stem Cells and Development, Published May 26 2016. doi: 10.1089/scd.2015.0394
All in a Droplet: Atomic Resolution of ALS Protein ResolvedNews
Researchers have described atom-by-atom changes in a family of proteins linked to amyotrophic lateral sclerosis (ALS), a group of brain disorders known as frontotemporal dementia and degenerative diseases of muscle and bone.READ MORE
Pupil Size Couples to Cortical States to Protect Deep Sleep StabilityNews
Researchers have found that mice pupil size fluctuates during sleep. They also show that pupil size is a reliable indicator of sleep states.READ MORE
A Place to Think: Persistent neuronal activity in human prefrontal cortex links perception and actionNews
Neuroscientists have tracked the progress of a thought through the brain, showing clearly how the prefrontal cortex at the front of the brain coordinates activity to help us act in response to a perception.READ MORE