Genetic pre-disposition toward exercise, mental development may be linked
News Apr 15, 2014
University of Missouri researchers have previously shown that a genetic pre-disposition to be more or less motivated to exercise exists. In a new study, Frank Booth, a professor in the MU College of Veterinary Medicine, has found a potential link between the genetic pre-disposition for high levels of exercise motivation and the speed at which mental maturation occurs.
For his study, Booth selectively bred rats that exhibited traits of either extreme activity or extreme laziness. Booth then put the rats in cages with running wheels and measured how much each rat willingly ran on their wheels during a six-day period. He then bred the top 26 runners with each other and bred the 26 rats that ran the least with each other. They repeated this process through 10 generations and found that the line of running rats chose to run 10 times more than the line of "lazy" rats.
Booth studied the brains of the rats and found much higher levels of neural maturation in the brains of the active rats than in the brains of the lazy rats.
"We looked at the part of the brain known as the 'grand central station,' or the hub where the brain is constantly sending and receiving signals," Booth said. "We found a big difference between the amount of molecules present in the brains of active rats compared to the brains of lazy rats. This suggests that the active rats were experiencing faster development of neural pathways than the lazy rats."
Booth says these findings may suggest a link between the genes responsible for exercise motivation and the genes responsible for mental development. He also says this research hints that exercising at a young age could help develop more neural pathways for motivation to be physically active.
"This study illustrates a potentially important link between exercise and the development of these neural pathways," Booth said. "Ultimately, this could show the benefits of exercise for mental development in humans, especially young children with constantly growing brains."
Booth's study, "Nucleus accumbens neuronal maturation differences in young rats bred for low versus high voluntary running behavior," was published in the Journal of Physiology.
Note: Material may have been edited for length and content. For further information, please contact the cited source.
M. D. Roberts, R. G. Toedebusch, K. D. Wells, J. M. Company, J. D. Brown, C. L. Cruthirds, A. J. Heese, C. Zhu, G. E. Rottinghaus, T. E. Childs, F. W. Booth. Nucleus accumbens neuronal maturation differences in young rats bred for low versus high voluntary running behavior. The Journal of Physiology, Published Online March 24 2014. doi: 10.1113/jphysiol.2013.268805
Longitudinal Study: Anxiety in Adults Could be Indicative of Alzheimer's DiseaseNews
Research team finds higher brain amyloid beta burden is associated with increasing anxiety symptoms over time in cognitively normal older adults.READ MORE
Preterm Babies Likely to Experience Delays in Auditory Cortex DevelopmentNews
Study shows preterm babies born early in the third trimester of pregnancy are likely to experience delays in the development of the auditory cortex, a brain region essential to hearing and understanding sound.READ MORE
Nanofabrication of Micropipettes Enables Simultaneous Electroporation of 250 Brain CellsNews
In a feat of nanoengineering, scientists have developed a new technique to map electrical circuits in the brain far more comprehensively than ever before.READ MORE