Guidelines bring Alzheimer's blood test one step closer
News May 22, 2015
A simple blood test to detect early Alzheimer's disease is a step closer to being used to screen older adults.
Detailed standardized guidelines that are needed before a blood test could be used in practice have been published in Alzheimer's & Dementia. The guidelines establish protocols and reflect the continued efforts of an international working group that includes University of North Texas Health Science Center (UNTHSC).
"If we are ever going to get a blood test for Alzheimer's disease into the hands of primary care providers, we must have guidelines," said Sid O'Bryant, PhD, Interim Director of the Institute of Aging and Alzheimer's Disease Research.
The highly rigid guidelines will be used in research for blood-based biomarkers of Alzheimer's disease and will ensure every lab is following the same procedures when collecting blood, said Dr. O'Bryant, a member of the group and lead author of the paper.
"You can create a blood test in the lab, but if you don't have a systemized way for collecting the blood, the test will never go into practice," he said. "You'll have one lab doing it one way and another lab doing something different."
Dr. O'Bryant has worked for several years with representatives from across the United States, Australia, Germany, England and other countries to create the standards. Everything from the type of needle used to draw blood to the length of the storage time is specified in the guidelines.
Just as with blood tests for other diseases, such as diabetes, protocols must be established to make sure every lab performs the test exactly the same. Such guidelines are needed before Food and Drug Administration (FDA) approval can be sought to use the test in a clinical setting.
"For UNTHSC, our next step is take these blood guidelines and implement them into a clinical trial," Dr. O'Bryant said. "That's never been done before."
Note: Material may have been edited for length and content. For further information, please contact the cited source.
Christoph Laske, Hamid R. Sohrabi, Shaun M. Frost, Karmele López-de-Ipiña, Peter Garrard, Massimo Buscema, Justin Dauwels, Surjo R. Soekadar, Stephan Mueller, Christoph Linnemann, Stephanie A. Bridenbaugh, Yogesan Kanagasingam, Ralph N. Martins, Sid E. O'Bryant. Innovative diagnostic tools for early detection of Alzheimer's disease. Alzheimer's & Dementia, Published May 2015. doi: 10.1016/j.jalz.2014.06.004
Researchers Find a Way to Separate Side Effects of Opioid Drugs Reducing RiskNews
Scientists have discovered a way to separate these two effects -- pain relief and breathing, opening a window of opportunity to make effective pain medications without the risk of respiratory failure.READ MORE
Biological Mechanism of a Leading Cause of Childhood Blindness RevealedNews
Scientists have revealed the pathology of cells and structures stricken by optic nerve hypoplasia, a leading cause of childhood blindness in developed nations.READ MORE
Machine Learning: Helping Determine How a Drug Affects the BrainNews
Machine learning could improve our ability to determine whether a new drug works in the brain, potentially enabling researchers to detect drug effects that would be missed entirely by conventional statistical tests, finds a new UCL study published today in Brain.READ MORE
Comments | 1 ADD COMMENT
Christian Labfinder | Nov 02, 2017
Hello everyone! If you want to get tested?…visit https://www.labfinder.com to Book a Test Time Location near you, and get your medical results fast.