Healthy tissue grafted to the brains of Huntington’s patients also develops signs of the disease
News Jun 05, 2014
A recent study published in Annals of Neurology reports that healthy human tissue grafted to the brains of patients with Huntington’s disease in the hopes of treating the neurological disorder also developed signs of the illness, several years after the graft. This discovery will have profound implications on our understanding of the disease and how to treat it, and may also lead to the development of new therapies for neurodegenerative disorders.
Huntington’s disease is a hereditary illness that causes the progressive breakdown of nerve cells in the brain, resulting in major motor, cognitive, and psychiatric impairments. It leads to a gradual loss of autonomy and, eventually, to death. The disease typically appears between age 40 and 50. There is no cure and current treatment methods only help control some of the symptoms without slowing down the disease itself.
“Until now, we thought that Huntington’s disease was exclusively the result of a genetic mutation within cells, an intrinsic phenomenon that gradually led to the manifestation of the illness,” explains Francesca Cicchetti, professor at the Université Laval Faculty of Medicine, researcher at the CHU de Québec Research Center, and lead author of the study. “However, our work shows that the mutant protein at the source of the illness can also spread from sick to healthy cells, which we did not expect.”
These findings by Dr. Cicchetti and her colleagues will have profound implications on the understanding of this pathology and how to treat it. It could also lead to the development of new therapies against other more common neurodegenerative disorders of the central nervous system, as well as diseases related to the propagation of pathological proteins, including Parkinson’s and Alzheimer’s.
Note: Material may have been edited for length and content. For further information, please contact the cited source.
F. Cicchetti, S. Lacroix, G. Cisbani, N. Vallières, M. Saint-Pierre, I. St-Amour, R. Tolouei, J.N. Skepper, R.A. Hauser, D. Mantovani, R.A. Barker, T.B. Freeman. Mutant huntingtin is present in neuronal grafts in Huntington's disease patients. Annals of Neurology, Published May 2014. doi: 10.1002/ana.24174
Researchers Democratize Neuroscience by Making it Easier to Share Brain Imaging DataNews
Researchers have developed a set of tools to make one critical area of big data research — that of our central nervous system — easier to share.READ MORE
Neuroscientists Identify The Retrosplenial Cortex as an Integrator of Vision and Head MovementNews
Study highlights role of primary visual cortex in integrating head and visual movement signalsREAD MORE
So Hot it Hurts: Ion channel trio underlying painful heat sensation foundNews
Researchers show that acute noxious heat sensing in mice depends on a triad of transient receptor potential (TRP) ion channels: TRPM3, TRPV1, and TRPA1.READ MORE