We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
Human Dark Proteome Initiative Launched
News

Human Dark Proteome Initiative Launched

Human Dark Proteome Initiative Launched
News

Human Dark Proteome Initiative Launched

Read time:
 

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "Human Dark Proteome Initiative Launched"

First Name*
Last Name*
Email Address*
Country*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

Scientists at St. Jude Children’s Research Hospital, The Scripps Research Institute (TSRI) and other institutions today announced the launch of the Human Dark Proteome Initiative (HDPI). The initiative aims to accelerate research into biology’s “invisible mass” to provide novel insights into cell function and a new frontier in drug discovery.

The term “dark proteome” describes the large portion of the proteome—the complete collection of proteins in an organism—that do not adopt defined 3D structures. These little-studied proteins make up about one third of the human proteome and control many aspects of cellular behavior. Recent developments in technology, including advances in nuclear magnetic resonance (NMR) spectroscopy methods, now make it possible to look in detail at these “intrinsically disordered proteins” (IDPs) and the “intrinsically disordered regions” (IDRs) of these molecules.

“Our goal is to raise awareness about the potential societal impacts of a broad-based research infrastructure for these understudied proteins,” saidRichard Kriwacki, Ph.D., a member of the St. Jude Department of Structural Biology and of the HDPI. “We also want to develop educational programs that will address the origins and potential cures of devastating diseases affected by these proteins that afflict large numbers of patients across the world.”

“IDPs are involved in heart disease, infectious disease, type 2 diabetes, cancer and many neurodegenerative diseases, such as Parkinson’s disease and Alzheimer’s disease,” said Peter Wright, Ph.D., who is Cecil H. and Ida M. Green Investigator at TSRI and chair of the HDPI. “We need to advance our understanding of the functions and molecular mechanisms of these proteins so we can work toward better therapies for these debilitating diseases.”

Wright and Kriwacki emphasized that dramatically expanded investment in basic and translational research into the dark proteome is needed to achieve the full potential for understanding and developing cures for many devastating diseases.

Advertisement