Imaging shows impact of PTSD in earthquake survivors
News Mar 01, 2016
Patients with posttraumatic stress disorder (PTSD) demonstrated alterations of cerebral structure, including increased cortical thickness in the right superior temporal gyrus, right inferior parietal lobule, and the left precuneus, and decreased volume of posterior corpus callosum, according to new research published online in the journal, Radiology.
Shiguang Li, MD, from the West China Hospital of Sichuan University in Sichuan, and colleagues recruited 67 patients with PTSD and 78 adult survivors without PTSD seven to 15 months after a devastating earthquake in western China. Averaged data from the regions with volumetric or cortical thickness differences between groups were extracted in each individual to examine correlations between morphometric measures and clinical profiles.
The total scores of Clinician-Administered PTSD Scale, which reflects PTSD illness severity, were positively correlated with cortical thickness in the left precuneus. Also, region-of-interest analysis demonstrated that the volume of posterior corpus callosum in patients with PTSD was smaller than in healthy survivors, and it was negatively correlated with cortical thickness in the left precuneus in patients with PTSD.
“We demonstrated a potential structural neural basis of default-mode network alterations in patients with PTSD that was related to clinical symptom severity. These findings significantly advance mechanistic understanding of early brain changes that determine whether severe emotional trauma will lead to PTSD,” the authors write.
Note: Material may have been edited for length and content. For further information, please contact the cited source.
Li S et al. Posttraumatic Stress Disorder: Structural Characterization with 3-T MR Imaging. Radiology, Published Online March 1 2016. doi: 10.1148/radiol.2016150477
Researchers Find a Way to Separate Side Effects of Opioid Drugs Reducing RiskNews
Scientists have discovered a way to separate these two effects -- pain relief and breathing, opening a window of opportunity to make effective pain medications without the risk of respiratory failure.READ MORE
Biological Mechanism of a Leading Cause of Childhood Blindness RevealedNews
Scientists have revealed the pathology of cells and structures stricken by optic nerve hypoplasia, a leading cause of childhood blindness in developed nations.READ MORE
Machine Learning: Helping Determine How a Drug Affects the BrainNews
Machine learning could improve our ability to determine whether a new drug works in the brain, potentially enabling researchers to detect drug effects that would be missed entirely by conventional statistical tests, finds a new UCL study published today in Brain.READ MORE