We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.


Major Molecular Medicine Centre Uses G:BOX iChemi XT Image Analyser

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "Major Molecular Medicine Centre Uses G:BOX iChemi XT Image Analyser"

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

Read time:
Syngene, announces its G:BOX iChemi XT imaging system is being used by researchers at a centre of excellence in the University of Portsmouth to help determine the molecular basis of life threatening disease, Duchenne’s muscular dystrophy.

Scientists in the School of Pharmacy and Biomedical Sciences at the University of Portsmouth are using a G:BOX iChemi XT system to accurately and quantitatively analyse Western blots of P2 receptors and other proteins associated with the dystrophin protein complex.

The blots are detected with either chemiluminescent ECL or different coloured fluorescent Dyomics dyes and the information gathered from them is used to determine which proteins have an impact on the pathology of muscular dystrophy, and could lead to the development of novel therapies for this fatal muscle wasting disease.

Professor Darek Gorecki, Director of Research in the School of Pharmacy and Biomedical Sciences stated: “We have identified P2 proteins affected by the absence of dystrophin and have produced knock-out mice to determine the effects that absence of P2 has in muscle cells. Since there is sometimes very small difference between up- and down-regulated proteins, we need an imaging system which can accurately detect low levels of protein and these very slight changes in expression levels.”

Professor Gorecki continued: “After looking at other imagers, we chose a G:BOX iChemi XT because it is less expensive than many systems, yet is versatile enough to capture low levels of light from blots using ECL imaging, as well as image and overlay different coloured fluorescent Westerns; giving us greater confidence in our qualitative data.”