We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
Mapping energy metabolism of growing nerve cells to better understand neuronal disorders
News

Mapping energy metabolism of growing nerve cells to better understand neuronal disorders

Mapping energy metabolism of growing nerve cells to better understand neuronal disorders
News

Mapping energy metabolism of growing nerve cells to better understand neuronal disorders

Read time:
 

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "Mapping energy metabolism of growing nerve cells to better understand neuronal disorders"

First Name*
Last Name*
Email Address*
Country*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

Scientists from Kyoto University's Institute for Integrated Cell-Material Sciences (iCeMS) in Japan have discovered how nerve cells adjust to low energy environments during the brain's growth process. Their study, published in the Journal of Neuroscience, may one day help find treatments for nerve cell damage and neurodegenerative disorders such as Alzheimer's and Parkinson's diseases.


Neurons in the brain have extraordinarily high energy demands due to the complex dendrites that expand to high volume and surface areas. It is also known that neurons are the first to die from restriction of blood supply to tissues, causing a shortage of oxygen and glucose needed for cellular metabolism. Little was known, however, on how cells adjust to low energy level environments in the developing brain, when mitochondria--the so-called "power plant" of the cell--do not get delivered on time, and a lag in the energy distribution occurs, which may lead to a variety of neurodegenerative disorders.


To unlock the mystery, the team studied mitochondria and energy consumption in a live, growing nerve cell over the course of a week.


"If neurons try to grow in low ATP energy levels, they could end up deformed, and even worse, put the life of the cell itself at stake," said Kansai Fukumitsu, who was involved in the study. "Since a single mitochondria in the root of the cell is not enough to supply energy to the nerve ends, the cell distributes mitochondria to its most outer branches to deliver power where energy levels are scarce."


In areas of low ATP energy concentrations, chemical changes were brought by molecular proteins, which stopped the dendrites from growing further.


"We found two protein molecules that synergistically produced enzymes to allocate energy molecules where it is direly needed for cellular survival," says Mineko Kengaku, the principal investigator of the study from iCeMS.


In the future, Kengaku and her co-authors envision treatments for incurable diseases by mapping the nerve cell metabolism in an energy-deprived state. "If we can get a better understanding of an unhealthy neuron, we may someday find ways to cure pathologies caused by them."


Note: Material may have been edited for length and content. For further information, please contact the cited source.

Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University   press release


Publication

K. Fukumitsu, K. Fujishima, A. Yoshimura, Y. K. Wu, J. Heuser, M. Kengaku. Synergistic Action of Dendritic Mitochondria and Creatine Kinase Maintains ATP Homeostasis and Actin Dynamics in Growing Neuronal Dendrites.   Journal of Neuroscience, Published April 8 2015. doi: 10.1523/JNEUROSCI.4115-14.2015


Advertisement