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ApoE4 Toxicity Mechanism in Alzheimer's Solved

News   Sep 20, 2017 | Original Story from the Washington University School of Medicine, St. Louis

Mechanism of ApoE4 Gene Toxicity in Alzheimer's Disease Neurodegeneration Solved

Parts of the brain important for memory have atrophied in a mouse carrying the high-risk Alzheimer's gene ApoE4, leaving a large fluid-filled hole in the brain (white area in photo at left), compared with a much smaller one in a mouse without the gene (right). A new study led by researchers at Washington University School of Medicine in St. Louis shows that the presence of ApoE4 exacerbates brain damage related to the Alzheimer's protein tau. Credit: Yang Shi



Strategy Could Help Treat Behavioral Abnormalities Linked to Autism


Researchers report in Nature Medicine a potential new treatment strategy for autism spectrum disorder – for which many cases are linked to mutated PTEN. Now, using Pten-deficient mice, researchers discover that a previously unexplored pathway goes “awry” in the brain, and by “rescuing” this pathway, it is possible to reverse behavioral and neurophysiological abnormalities.


Ranitidine Recalled Due to Potential Carcinogen Contamination


Teva UK Ltd is recalling unexpired stock of certain batches of two types of Ranitidine medicines – used to treat conditions such as heartburn and stomach ulcers.


A Counting Game: Quantifying CRISPR’s Off-target Effects


Scientists are finding new ways to improve the use of the CRISPR enzyme Cas9 and reduce the chances of off-target mutations in laboratory mice, according to new results.



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