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ApoE4 Toxicity Mechanism in Alzheimer's Solved

News   Sep 20, 2017 | Original Story from the Washington University School of Medicine, St. Louis

Mechanism of ApoE4 Gene Toxicity in Alzheimer's Disease Neurodegeneration Solved

Parts of the brain important for memory have atrophied in a mouse carrying the high-risk Alzheimer's gene ApoE4, leaving a large fluid-filled hole in the brain (white area in photo at left), compared with a much smaller one in a mouse without the gene (right). A new study led by researchers at Washington University School of Medicine in St. Louis shows that the presence of ApoE4 exacerbates brain damage related to the Alzheimer's protein tau. Credit: Yang Shi



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