We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
Metabolomic Study Links Asthma Treatment to Adrenal Suppression
News

Metabolomic Study Links Asthma Treatment to Adrenal Suppression

Metabolomic Study Links Asthma Treatment to Adrenal Suppression
News

Metabolomic Study Links Asthma Treatment to Adrenal Suppression

Credit: Bob Williams/ Pixabay
Read time:
 

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "Metabolomic Study Links Asthma Treatment to Adrenal Suppression"

First Name*
Last Name*
Email Address*
Country*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

Inhaled cortical steroids (ICS) can help patients manage asthma symptoms, and recent updates to asthma treatment guidelines have expanded recommended, low-dose treatment. But concerns persist that ICS may reduce production of the steroid hormone cortisol in the body leading to adrenal suppression. While initial adrenal suppression symptoms are subtle, continued progression can lead to fatigue, headache, abdominal pain, vomiting and psychiatric symptoms.


Until now, studies of ICS and adrenal suppression have been limited and have produced conflicting findings.  To better understand the association between ICS and adrenal suppression, researchers from Brigham and Women’s Hospital and the University of Cambridge conducted the largest metabolomic study of asthma to date. By analyzing the blood plasma  of 14,000 individuals from four independent study cohorts, the team identified 17 steroid metabolites that were reduced in individuals with asthma and found that, even among patients taking low-dose ICS, ICS usage was associated with reduced cortisol levels.


In the Nature Medicine paper reporting their results, the researchers also found significant associations between adrenal insufficiency symptoms, including fatigue and anemia, in asthma patients taking ICS treatment compared to those who were not.


Co-senior author Dr Jessica Lasky-Su, of the Channing Division of Network Medicine at Brigham and Women’s Hospital, said:

The use of ICS has been instrumental in reducing asthma exacerbations and improving overall quality of life. However, while their effectiveness should not be understated, our findings suggest that the risks of ICS usage must also be considered.”

Co-senior author Dr Claudia Langenberg, of the MRC Epidemiology Unit at the University of Cambridge, UK, and Berlin Institute of Health at Charité Universitätsmedizin, Germany, added:

Our work suggests that simple measures, such as regular cortisol monitoring and prescription of the lowest effective ICS dose, may help to mitigate the systemic side effects of ICS use”

Reference: Kachroo P, Stewart ID, Kelly RS, et al. Metabolomic profiling reveals extensive adrenal suppression due to inhaled corticosteroid therapy in asthma. Nat Med. 2022. doi: 10.1038/s41591-022-01714-5

  

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.


Advertisement