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Mutated Neuron Antennae Can Lead to Neurodevelopmental Disorders

News   Dec 17, 2019 | Original story from UNC Health

 
Mutated Neuron Antennae Can Lead to Neurodevelopmental Disorders

Credit: Appropriate axonal growth and connectivity are essential for the functional wiring of the brain. In the current issue of Developmental Cell, Anton and colleagues show that signals emanating from primary cilia regulate axonal development and connectivity of projection neurons in the developing brain. The image shows disrupted crisscrossing and organization of axons (yellow) following neuron specific deletion of primary cilia and Joubert syndrome-related gene, Arl13b. Credit: Anton lab

 
 
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