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Dynorphin Drives Anxiety

News   May 30, 2018 | Original Story by Chris Palmer for Cold Spring Harbour

Neuropeptide of Stress: Dynorphin drives anxiety

Anxiety was traced by the CSHL team to the brain's central amygdala, and to increased excitation of neurons that express the peptide somatostatin (SOM+ neurons). This initial step is demonstrated in these images, by comparing the amount of pink and blue fluorescence in the bottom right frame as compared with the frame directly above it, showing the central amygdala in mice not experiencing anxiety. The full pathway involves additional steps and identifies dynorphin, a signaling molecule, as a possible anti-anxiety drug target.



From Ion Channels to Whole Brain Stimulation


Pores at the surface of neurons and muscle cells control your every thought, movement; the very beating of your heart. The way the pores behave shapes signals in the form of ions moving across the cell surface. For the first time, researchers have mapped the behavior of the largest family of these voltage-gated ion channels: Kv channels.


Kids Need More Sleep, Less Screen, Says HALO Group


A paper published today in Pediatrics suggests that children and youth who do not sleep enough and use screens more than recommended are more likely to act impulsively and make poorer decisions.


Watching the Brain's "Firework Memories"


A new paper a neuronal mechanism central to human free recall that sees orchestrated burst of synchronous activation by about 15% of hippocampal neurons.



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