We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
New computational strategy finds brain tumor-shrinking molecules
News

New computational strategy finds brain tumor-shrinking molecules

New computational strategy finds brain tumor-shrinking molecules
News

New computational strategy finds brain tumor-shrinking molecules

Read time:
 

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "New computational strategy finds brain tumor-shrinking molecules"

First Name*
Last Name*
Email Address*
Country*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

Computer modeling identifies first-ever molecule to inhibit a transient cellular event that drives glioblastoma, and the molecule shrinks glioblastoma in mice -


Patients with glioblastoma, a type of malignant brain tumor, usually survive fewer than 15 months following diagnosis. Since there are no effective treatments for the deadly disease, University of California (UC), San Diego researchers have developed a new computational strategy to search for molecules that could be developed into glioblastoma drugs. In mouse models of human glioblastoma, one molecule they found shrank the average tumor size by half. The study is published by Oncotarget.


The newly discovered molecule works against glioblastoma by wedging itself in the temporary interface between two proteins whose binding is essential for the tumor's survival and growth. This study is the first to demonstrate successful inhibition of this type of protein, known as a transcription factor.


"Most drugs target stable pockets within proteins, so when we started out, people thought it would be impossible to inhibit the transient interface between two transcription factors," said first author Igor Tsigelny, PhD, research scientist at UC San Diego Moores Cancer Center, as well as the San Diego Supercomputer Center and Department of Neurosciences at UC San Diego. "But we addressed this challenge and created a new strategy for drug design -- one that we expect many other researchers will immediately begin implementing in the development of drugs that target similar proteins, for the treatment of a variety of diseases."


Transcription factors control which genes are turned "on" or "off" at any given time. For most people, transcription factors labor ceaselessly in a highly orchestrated system. In glioblastoma, one misfiring transcription factor called OLIG2 keeps cell growth and survival genes "on" when they shouldn't be, leading to quick-growing tumors.


In order to work, transcription factors must buddy up, with two binding to each other and to DNA at same time. If any of these associations are disrupted, the transcription factor is inhibited.


In this study, Tsigelny and team aimed to disrupt the OLIG2 buddy system as a potential treatment for glioblastoma. Based on the known structure of related transcription factors, study co-author Valentina Kouznetsova, PhD, associate project scientist at UC San Diego, developed a computational strategy to search databases of 3D molecular structures for those small molecules that might engage the hotspot between two OLIG2 transcription factors. The team used the Molecular Operation Environment (MOE) program produced by the Chemical Computing Group in Montreal, Canada and high-performance workstations at the San Diego Supercomputer Center to run the search.


With this approach, the researchers identified a few molecules that would likely fit the OLIG2 interaction. They then tested the molecules for their ability to kill glioblastoma tumors in the Moores Cancer Center lab of the study's senior author, Santosh Kesari, MD, PhD. The most effective of these candidate drug molecules, called SKOG102, shrank human glioblastoma tumors grown in mouse models by an average of 50 percent.


"While the initial pre-clinical findings are promising," Kesari cautioned, "it will be several years before a potential glioblastoma therapy can be tested in humans. SKOG102 must first undergo detailed pharmacodynamic, biophysical and mechanistic studies in order to better understand its efficacy and possible toxicity."


To this end, SKOG102 has been licensed to Curtana Pharmaceuticals, which is currently developing the inhibitor for clinical applications. Kesari is a co-founder, has an equity interest in and is chair of the scientific advisory board for Curtana Pharmaceuticals. Co-authors Rajesh Mukthavaram, PhD, and Wolfgang Wrasidlo, PhD, also own stock in Curtana Pharmaceuticals


Note: Material may have been edited for length and content. For further information, please contact the cited source.

University of California, San Diego   press release


Publication

Kesari S et al. Multiple spatially related pharmacophores define small molecule inhibitors of OLIG2 in glioblastoma.   Oncotarget, Published October 30 2015. doi: 10.18632/oncotarget.5633


Advertisement