Stress as Harmful as Junk Food
We all know that a poor diet is unhealthy, but a new BYU study finds that stress may be just as harmful to our bodies as a really bad diet.
In a new paper published in Nature Scientific Reports, BYU professor of microbiology and molecular biology Laura Bridgewater found that when female mice were exposed to stress, their gut microbiota — the microorganisms vital to digestive and metabolic health — changed to look like the mice had been eating a high-fat diet.
“Stress can be harmful in a lot of ways, but this research is novel in that it ties stress to female-specific changes in the gut microbiota,” Bridgewater said. “We sometimes think of stress as a purely psychological phenomenon, but it causes distinct physical changes.”
Bridgewater and her collaborators at Shanghai Jiao Tong University in China took a large group of 8-week-old mice and exposed half of the males and half of the females to a high-fat diet. After 16 weeks, all of the mice were exposed to mild stress over the course of 18 days.
Researchers then extracted microbial DNA from the mice fecal pellets before and after the stress to test how the gut microbiota was affected. They also measured mouse anxiety based on how much and where the mice traveled in an open field arena.
The researchers found fascinating differences between genders: Male mice on the high-fat diet exhibited more anxiety than females on the high-fat diet, and high-fat males also showed decreased activity in response to stress. However, it was only in female mice that stress caused the gut microbiota composition to shift as if the animals were on a high-fat diet.
While the study was only carried out on animals, researchers believe there could be significant implications for humans.
“In society, women tend to have higher rates of depression and anxiety, which are linked to stress” said Bridgewater, who also serves as Associate Dean of the BYU College of Life Sciences. “This study suggests that a possible source of the gender discrepancy may be the different ways gut microbiota responds to stress in males vs. females.”
This article has been republished from materials provided by Brigham Young University. Note: material may have been edited for length and content. For further information, please contact the cited source.
Bridgewater, L. C., Zhang, C., Wu, Y., Hu, W., Zhang, Q., Wang, J., . . . Zhao, L. (2017). Gender-based differences in host behavior and gut microbiota composition in response to high fat diet and stress in a mouse model. Scientific Reports, 7(1).
Avatar Therapy Successfully Treats Schizophrenic Patients Suffering from Auditory HallucinationsNews
Researchers found that avatar therapy was more effective at reducing hallucinations than counseling.READ MORE
Abnormal Prion Protein Found in the Skin of Patients That Died of CJDNews
Scientists have detected abnormal prion protein in the skin of nearly two dozen people who died from Creutzfeldt-Jakob disease (CJD).READ MORE
Whole-Brain Map of Memory Circuits Constructed from Human DataNews
The work elucidates the way different regions of the brain communicate during cognitive processes like memory formation.READ MORE