Population Genetics Collaborate with University of Oxford
News Jun 18, 2012
Two leading research groups at the University of Oxford will use Population Genetics Technologies to enable studies on gene variants associated with myocardial infarction, diabetes and metabolic disease.
The first two Oxford studies to exploit this agreement are led by Mark McCarthy, Robert Turner Professor of Diabetes at the Oxford Centre for Diabetes, Endocrinology and Metabolism, and David Buck, Head of High Throughput Genomics at the Wellcome Trust Centre for Human Genetics (WTCHG).
The McCarthy group will work in partnership with Population Genetics on a population study of 74 exons from 12 genes across a population of 1000 genomic DNA samples to identify genetic associations with diabetes and metabolic disease, using the company’s GenomePooling™ technology.
The studies will also inform a wider initiative led by the National Institute for Health Research (NIHR) to establish an NIHR BioResource of volunteers willing to participate in research that will map genotype to phenotype.
The Buck group, in collaboration with PROCARDIS, will use Population Genetics’ Reflex™ workflow to interrogate 3000 samples and identify genetic variants of candidate genes associated with myocardial infarction.
Based on the work of one of the company’s founders, Nobel Laureate Sydney Brenner, GenomePooling™ allows multiple genes and discontiguous regions of DNA, such as those identified by genome-wide association studies, to be simultaneously sequenced across entire populations quickly and cost-effectively while still being queriable down to the level of the individual.
Reflex™ also focuses on large populations but is used where the target is a single large contiguous region such as a whole gene.
Commented Mark McCarthy: “Population Genetics gives us an efficient way to validate hypotheses through identification of variants in candidate genes associated with common human diseases. This partnership will make a valuable difference in our ability to progress our studies towards clinical application.”
Alan Schafer, CEO of Population Genetics, said: “We are pleased by the recognition given to our capability and to our enabling technologies, demonstrated in the formation of the partnerships with researchers as esteemed as Mark McCarthy and David Buck. We look forward to providing key capability to them and to others at the University of Oxford that will help advance genetic research towards clinical application.”
Tiny “Tornado” Boosts Performance of Electrospray Ionization Mass SpectrometryNews
Known as Dry Ion Localization and Locomotion (DRILL), the new device creates a swirling flow that can separate electrospray droplets depending on their size.READ MORE
CRISPR Reveals New Targets for Promising Cancer DrugsNews
Novel screening method identifies new drug targets that could potentially enhance the effectiveness of PD-1 checkpoint inhibitors, a promising new class of cancer immunotherapy.READ MORE
Study Indicates 75% of Human Genome is Non-functionalNews
An evolutionary biologist at the University of Houston has published new calculations that indicate no more than 25 percent of the human genome is functional.READ MORE
Comments | 0 ADD COMMENT
11th Edition of International Conference on Proteomics 2018
Mar 22 - Mar 23, 2018
EMBL Course: Next Generation Sequencing: RNA Sequencing Library Preparation
Apr 23 - Apr 27, 2018
EMBO Practical Course: Microbial Metagenomics: A 360º Approach
Apr 23 - Apr 30, 2018