We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
Post-Stroke Intranasal (+)-Naloxone Improves Stroke Outcome
News

Overdose Drug Improves Stroke Outcome

Post-Stroke Intranasal (+)-Naloxone Improves Stroke Outcome
News

Overdose Drug Improves Stroke Outcome

Credit: Pixabay
Read time:
 

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "Post-Stroke Intranasal (+)-Naloxone Improves Stroke Outcome"

First Name*
Last Name*
Email Address*
Country*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

The life-saving drug used to treat opioid overdose, naloxone, reduces brain inflammation in the aftermath of stroke in male rats. The preclinical research, published in eNeuro, lays the groundwork for developing the first drug to promote recovery from a leading cause of adult disability.

Naloxone has been used for decades to prevent death from drug overdose and has become widely used in recent years in response to the unrelenting opioid crisis. Although the therapeutic potential of naloxone in stroke has been explored, research in this area is limited to a few case studies from the 1980s and inconclusive clinical trials.

Brandon Harvey, Mikko Airavaara, and colleagues expand on this work by showing in a rat model of stroke that one week of treatment with naloxone, beginning one day after the stroke, tempered the brain's immune response in the first week and improved neurological function in the second week. A form of naloxone that has limited interaction with opioid receptors had similar effects as the one used in overdose treatment, which may circumvent the side effects of activating the opioid system. As with the naloxone nasal spray Narcan, the researchers administered the drug to rats though the nose at doses similar to those that have been shown to be safe in humans. Together, these initial findings warrant further study of naloxone in different populations of animals and over a longer recovery period to investigate its potential for promoting recovery from stroke in humans.

This article has been republished from materials provided by SfN. Note: material may have been edited for length and content. For further information, please contact the cited source.

Reference:
Anttila, J. E., Albert, K., Wires, E. S., Mätlik, K., Loram, L., Watkins, L., . . . Airavaara, M. (2018). Post-Stroke Intranasal ( )-Naloxone Delivery Reduces Microglial Activation and Improves Behavioral Recovery from Ischemic Injury. Eneuro. doi:10.1523/eneuro.0395-17.2018 



Advertisement