Predicting the severity of multiple sclerosis
News Sep 14, 2016
Cells in the immune system of patients with multiple sclerosis behave differently from those of healthy individuals. Researchers at Linköping University in Sweden have exploited this difference to develop a method that can predict disease activity in multiple sclerosis.
It is not currently possible to know which individuals with multiple sclerosis risk developing severe disease. Multiple sclerosis (MS), is an inflammatory disease of the central nervous system that mainly affects young adults. The disease is a life-long condition.
The researchers behind the new study hope that the method they have developed will contribute to answering the question why certain patients suffer less severely with the disease than others. Eventually, a test may be developed for use in patient management.
The new study, published in the journal Cell Reports, describes how the researchers have sought biomarkers that can be used in MS. Biomarkers are naturally occurring substances in the body that can be measured in, for example, blood and that mirror a condition in the body. They are used in medical care to follow the progression of a disease and measure the effect of a treatment. The researchers compared immune cells from patients with MS with cells from healthy controls. They discovered important differences in the functioning of cells from healthy and sick individuals. The researcher investigated how large numbers of proteins interact with each other, and used new bioinformatics methods to find those that are highly significant in MS.
"We have been able to study in detail changes in the immune cells of patients, and been able to identify important proteins. This has led us to a biomarker that can predict how the disease will progress in the patient," says bioinformatics specialist Mika Gustafsson, who has led the study together with Professor Jan Ernerudh.
The biomarker that the researchers have identified is a combination of four proteins, whose concentrations in cerebrospinal fluid can be measured. In the study, it was possible for the researchers to predict with the aid of the biomarker which patients with MS would have active MS disease two years later. The new method was also able to predict the efficacy of a common MS drug in a small group of patients.
"Being able to determine the prognosis more accurately is a huge step forward when it comes to choosing the correct treatment," says Jan Ernerudh, professor of clinical immunology.
The project is a collaboration between researchers at Linköping University, Linköping University Hospital and Karolinska Institutet. It has received grants from, among other sources, the Swedish Research Council, the Medical Research Council of Southeast Sweden (FORSS), the Swedish Foundation for MS Research and Neuro Sweden.
Note: Material may have been edited for length and content. For further information, please contact the cited source.
Hellberg S et al. Dynamic Response Genes in CD4+ T Cells Reveal a Network of Interactive Proteins that Classifies Disease Activity in Multiple Sclerosis. Cell Reports, Published September 13 2016. doi: 10.1016/j.celrep.2016.08.036
We make judgements quite rationally or "by the gut". Not only experience and relevant information play an important role, but also our preferences. A study by the Max Planck Institute for Metabolism Research in Cologne shows how the reward system in the brain conveys judgements affected by one's own desires, and how our inner beliefs are altered more by good than bad news.
The emerging technology of sonogenetics—a technique where cells are controlled by sound—offers the potential to one day replace pharmaceutical drugs or invasive surgical treatments for neurological conditions like epilepsy, Parkinson’s disease or post-traumatic stress disorder. A new research program could take this technique to the next level with $750,000 of funding.READ MORE
5th International Congress on Epigenetics & Chromatin
Aug 22 - Aug 23, 2019
International Conference on e-Health and Healthcare Innovations
May 08 - May 09, 2019