Reduced brain connectivity in frontal cortex linked to propofol-induced loss of consciousness
News Apr 15, 2016
A new study shows that loss of responsiveness induced by propofol, a commonly used anesthetic, is associated with greatly diminished brain connectivity in the frontal cortex and significant changes in resting state brain networks.
The study, based on a novel method for constructing total brain connectivity maps and comparing them with results obtained for resting state networks, is published in Brain Connectivity.
Pieter Guldenmund and coauthors from University of Liège and CHR Hospital Citadelle (Liège, Belgium), National University of Colombia and Central University of Colombia (Bogotá), University of Western Ontario (London, Canada), and University of Wisconsin (Madison), used resting-state functional magnetic resonance imaging (fMRI) to determine changes in resting state brain networks, total brain connectivity, and mean oscillation frequencies of the regional blood oxygenation level dependent (BOLD) signal associated with propofol-induced mild sedation and loss of consciousness. The researchers conclude that diminished connectivity in the frontal lobes plays an important role in propofol-induced loss of responsiveness.
"Very little is understood about the biological mechanism of how an anesthetic produces sedation and loss of consciousness, especially in the brain," says Christopher Pawela, PhD, Co-Editor-in-Chief of Brain Connectivity and Assistant Professor of Anesthesiology, Medical College of Wisconsin. "Pieter Guldenmund and his colleagues have produced an elegant study using resting-state functional connectivity MRI to implicate the frontal lobes in the mechanism of action of propofol in the brain."
Note: Material may have been edited for length and content. For further information, please contact the cited source.
Guldenmund P et al. Propofol-Induced Frontal Cortex Disconnection: A Study of Resting-State Networks, Total Brain Connectivity, and Mean BOLD Signal Oscillation Frequencies. Brain Connectivity, Published March 31 2016. doi: 10.1089/brain.2015.0369
Therapeutic Avenue for Parkinson's Disease?News
A new potential therapeutic avenue for Parkinson's disease. This research is unusual given that it focuses on senescence in astrocytes, so called "helper" cells that perform a variety of tasks, from axon guidance and synaptic support to control of the blood brain barrier and blood flow.READ MORE
Using Epigenetic Signatures and Machine Learning to Improve DiagnosisNews
Unique epigenetic signatures for nine neurodevelopmental disorders have been identified, lending to a better method of diagnosis for disorders with much clinical overlap.READ MORE
Valence Mapped: Brain study reveals roots of desire and dislike in the amygdalaNews
Researchers map the amygdala's distinct but diverse and dynamic neighbourhoods where feelings are assigned.READ MORE