Research sheds light on how neurons control muscle movement
News Jun 23, 2015
Stanford University researchers studying how the brain controls movement in people with paralysis, related to their diagnosis of amyotrophic lateral sclerosis (ALS), have found that groups of neurons work together, firing in complex rhythms to signal muscles about when and where to move.
"We hope to apply these findings to create prosthetic devices, such as robotic arms, that better understand and respond to a person's thoughts," said Jaimie Henderson, MD, professor of neurosurgery.
A paper describing the study is published in the journal eLife. Henderson, who holds the John and Jene Blume-Robert and Ruth Halperin Professorship, and Krishna Shenoy, PhD, professor of electrical engineering and a Howard Hughes Medical Institute investigator, share senior authorship of the paper. The lead author is postdoctoral scholar Chethan Pandarinath, PhD.
The study builds on groundbreaking Stanford animal research that fundamentally has changed how scientists think about how motor cortical neurons work to control movements. "The earlier research with animals showed that many of the firing patterns that seem so confusing when we look at individual neurons become clear when we look at large groups of neurons together as a dynamical system," Pandarinath said.
Previously, researchers had two theories about how neurons in the motor cortex might control movement: One was that these neurons fired in patterns that represent more abstract commands, such as "move your arm to the right," and then neurons in different brain areas would translate those instructions to guide the muscle contractions that make the arm move; the other was that the motor cortex neurons would actually send directions to the arm muscles, telling them how to contract.
But in an animal study published in Nature in 2012, Shenoy and his colleagues reported finding that much more is going on: Motor cortical neurons work as part of an interconnected circuit -- a so-called dynamical system -- to create rhythmic patterns of neural activity. As these rhythmic patterns are sent to the arm, they drive muscle contractions, causing the arm to move.
"What we discovered in our preclinical work is evidence of how groups of neurons coordinate and cooperate with each other in a very particular way that gives us deeper insight into how the brain is controlling the arm," Shenoy said.
He and his colleagues wanted to know whether neurons fired similarly in humans.
Recording human brain activity
To conduct the study, the researchers recorded motor cortical brain activity of two research participants with ALS. The condition, which also is known as Lou Gehrig's disease, damages neurons and causes patients to lose control over their muscles.
The participants, a 51-year-old woman who retained some movement in her fingers and wrists and a 54-year-old man who could still move one of his index fingers slightly, are participants in the BrainGate2 trial, which is testing a neural interface system allowing thoughts to control computer cursors, robotic arms and other assistive devices.
These participants had electrode arrays implanted in their brains' motor cortex for the trial. That allowed researchers to record electrical brain activity from individual neurons while the participants moved or tried to move their fingers and wrists, which were equipped with sensors to record physical movement. Typically, such mapping in humans can only occur during brain surgery.
The participants' implants provided an "opportunity to ask important scientific questions," Shenoy said. The researchers found that the ALS patients' neurons worked very similarly to the preclinical research findings.
Researchers now plan to use their data to improve the algorithms that translate neural activity in the form of electrical impulses into control signals that can guide a robotic arm or a computer cursor.
Note: Material may have been edited for length and content. For further information, please contact the cited source.
Shenoy KV et al. Neural population dynamics in human motor cortex during movements in people with ALS. eLife, Published June 23 2015. doi: 10.7554/eLife.07436
Catalyst Can Degrade Alzheimer's-Related Amyloid Peptide Under Near-Infrared LightNews
A new, biocompatible photooxygenation catalyst that can selectively oxygenate and degrade the pathogenic aggregation of Alzheimer's disease (AD)-related amyloid-β peptide (Αβ) under near-infrared (NIR) light irradiation has been developed.READ MORE
Comments | 0 ADD COMMENT
World Congress on Pathology and Laboratory Medicine
Sep 10 - Sep 11, 2018
World Congress on Advances in Addiction Science and Medicine
Sep 24 - Sep 25, 2018