Research sheds new light on the cause of chronic fatigue syndrome/myalgic encephalomyelitis
News May 13, 2015
New research findings may shed light on the potential cause of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME).
Researchers from Griffith University’s National Centre for Neuroimmunology and Emerging Diseases (NCNED) – part of the new Menzies Health Institute Queensland (Australia) – have uncovered significant factors contributing to the pathology of this illness.
The results reveal genetic changes in important receptors associated with immunological and cellular function and contribute to the development of this complex illness.
“These findings have been achieved through a team effort involving researchers, patients, funding bodies, clinicians and the support of Griffith University and the Queensland Government,” say chief investigators Professor Sonya Marshall-Gradisnik and Professor Donald Staines.
Co-researcher and consultant immunologist Professor Pete Smith said that important signalling mechanisms are disrupted as a result of these genetic changes involving the detection and response to threats.
“These are primitive genes that are involved in many cellular signals in the brain, gut, cardiovascular and immune systems, as well as in the mediation of pain.”
CFS/ME is a highly debilitating disorder characterized by profound fatigue, muscle and joint pain, cerebral symptoms of impaired memory and concentration, impaired cardiovascular function, gut disorder and sensory dysfunction such as noise intolerance and balance disturbance. Many cases can continue for months or years.
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Sonya Marshall-Gradisnik, Donald Staines, Pete Smith, Bernd Nilius, Ekua Brenu, Sandra Ramos. Examination of Single Nucleotide Polymorphisms (SNPs) in Transient Receptor Potential (TRP) Ion Channels in Chronic Fatigue Syndrome Patients. Immunology and Immunogenetics Insights, Published May 10 2015. doi: 10.4137/III.S25147
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