Righting a wrong? Right side of brain can compensate for post-stroke loss of speech
News Nov 03, 2015
After a debate that has lasted more than 130 years, researchers at Georgetown University Medical Center have found that loss of speech from a stroke in the left hemisphere of the brain can be recovered on the back, right side of the brain. This contradicts recent notions that the right hemisphere interferes with recovery.
While the findings will likely not put an immediate end to the debate, they suggest a new direction in treatment.
The study, published in the journal Brain, is the first to look at brain structure and gray matter volume when trying to understand how speech is recovered after a stroke. Results show that patients who have regained their voice have increased gray matter volume in the back of their right hemisphere—mirroring the location of one of the two left hemisphere speech areas.
"Over the past decade, researchers have increasingly suggested that the right hemisphere interferes with good recovery of language after left hemisphere strokes," says the study's senior author, Peter Turkeltaub, MD, PhD, an assistant professor of neurology at Georgetown University Medical Center and director of the aphasia clinic at MedStar National Rehabilitation Network. "Our results suggest the opposite—that right hemisphere compensation improves recovery."
Approximately one-third of stroke survivors lose speech and language—a disorder called aphasia—and most never fully regain it. Turkeltaub says loss of speech occurs almost exclusively in patients with a left hemisphere stroke—roughly 70 percent of people with left hemisphere strokes have language problems.
In a group of 32 left-hemisphere stroke survivors, the researchers determined whether increased gray matter volume in the right hemisphere related to better than expected speech abilities, given the individual features of each person's stroke. The researchers enrolled an additional 30 individuals who had not experienced a stroke as a control group.
The investigators found that stroke participants who had better than expected speech abilities after their stroke had more gray matter in the back of the right hemisphere compared to stroke patients with worse speech. Those areas of the right hemisphere were also larger in the stroke survivors than in the control group, Turkeltaub says. "This indicates growth in these brain areas that relates to better speech production after a stroke."
Turkeltaub, a member of the Center for Brain Plasticity and Recovery at Georgetown University and MedStar National Rehabilitation Network, and his colleagues are continuing their study, looking for areas that compensate for other aspects of language use, such as comprehension of speech. The speech center discovered by the team aids only in use of speech, not in understanding what is said to an affected stroke patient.
Note: Material may have been edited for length and content. For further information, please contact the cited source.
Turkeltaub PE et al. Right hemisphere grey matter structure and language outcomes in chronic left hemisphere stroke. Brain, Published Online October 31 2015. doi: 10.1093/brain/awv323
Combination Chemotherapy Could Significantly Improve Deadly Brain Tumor TreatmentNews
A team led by Massachusetts General Hospital (MGH) investigators has found that adding the chemotherapy drug hydroxyurea to the current chemotherapy protocol for glioblastoma significantly increased survival in animal models.READ MORE
Purine Synthesis in Neuron-Like Cells InvestigatedNews
Neuron-like cells created from a readily available cell line have allowed researchers to investigate how the human brain makes a metabolic building block essential for the survival of all living organisms.READ MORE
All in a Droplet: Atomic Resolution of ALS Protein ResolvedNews
Researchers have described atom-by-atom changes in a family of proteins linked to amyotrophic lateral sclerosis (ALS), a group of brain disorders known as frontotemporal dementia and degenerative diseases of muscle and bone.READ MORE