Some patients in a vegetative state retain awareness, despite being unable to move
News Oct 19, 2015
New insight into a vital cerebral pathway has explained how some patients in a vegetative state are aware despite appearing to be unconscious and being behaviorally unresponsive.
The findings, published in JAMA Neurology, identify structural damage between the thalamus and primary motor cortex as the obstacle between covert awareness and intentional movement.
The team of researchers hope that their study, the first to understand the phenomenon, will pave the way for the development of restorative therapies for thousands of patients.
Dr. Davinia Fernández-Espejo, from the University of Birmingham, explained, "A number of patients who appear to be in a vegetative state are actually aware of themselves and their surroundings, able to comprehend the world around them, create memories and imagine events as with any other person."
"However, before we take the crucial step of developing targeted therapies to help these patients, we needed to identify the reason for the dissociation between their retained awareness and their inability to respond with intentional movement."
"In highlighting damage to the pathways that physically connect the thalamus, one of the hubs of consciousness if you will, and the motor cortex, which drives our voluntary muscular activity, as the reason behind the dissociation we have provided an important explanation".
A patient who produced repeated evidence of covert awareness across multiple examinations, despite being in a vegetative state for over 12 years, was observed in a case study at the imaging centre at the Brain and Mind Institute, at Western University, in London, Canada.
A fellow patient with similar clinical variables, but capable of intentional movement, and 15 healthy control volunteers were also monitored using functional magnetic resonance imaging (fMRI) and fiber tractography.
Participants were asked to respond to commands, for example, asking them to imagine moving their hand in response to the keyword "move", while their brain activity was measured. Additionally, the researchers assessed the integrity of the structural pathways that were revealed as essential for successful motor execution (those connecting the thalamus with the motor cortex).
Dr. Fernández-Espejo added, "The ultimate aim is to use this information in targeted therapies that can drastically improve the quality of life of patients. For example, with the advances being made in assistive technology, if we can help a patient to regain even limited movement in one finger it opens up so many possibilities for communication and control of their environment."
Though it may be a number of years before an effective therapy is developed, the team believe that a significant milestone has been reached with the discovery.
Note: Material may have been edited for length and content. For further information, please contact the cited source.
Fernández-Espejo D, Rossit S, Owen AM. A Thalamocortical Mechanism for the Absence of Overt Motor Behavior in Covertly Aware Patients. JAMA Neurology, Published Online October 19 2015. doi: 10.1001/jamaneurol.2015.2614
Synaptotagmin 7 Ensures Efficiency of Inhibitory Signal TransmissionNews
Researchers at IST Austria define function of an enigmatic synaptic protein, synaptotagmin 7.READ MORE
Molecules in Spit Could Help Diagnose ConcussionsNews
Diagnosing a concussion can sometimes be a guessing game, but clues taken from small molecules in saliva may be able to help diagnose and predict the duration of concussions in children, according to Penn State College of Medicine researchers.READ MORE
Elpis BioMed Closes Funding Round to Commercialise Novel Technology Platform for Generating Human Cell TypesNews
New Cambridge spin-out company commercialises disruptive technology that enables rapid generation of pure and consistent batches of human cell types. Geographically diversified, top-tier investor team includes key industry leaders to support early company development.READ MORE