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New Huntington's Disease Stem Cell Model

News   Feb 06, 2018 | By Julia Evangilou Strait for WUSTL

Stem Cells From Huntington's Patients Made Into Neurons, Recapitulate the Disease

Pictured are reprogrammed cells from a 71-year-old patient with Huntington's disease. Originally skin cells, these have been converted into medium spiny neurons, the cell type affected in Huntington's disease. Sampling skin cells from patients and converting them directly into neurons affected by the disorder is a new tool to help understand why nerve cells die in this fatal condition.



Drugs to Prevent Stroke and Dementia Show Promise in Early Trial


Treatments that prevent recurrence of types of stroke and dementia caused by damage to small blood vessels in the brain have moved a step closer, following a small study.


How a Shrub May Enable the “Impossible” in Treating Addiction


Scientists used a compound found in a shrub native to Africa to reveal the three major shapes of the serotonin transporter, a protein in the brain linked to anxiety and depression.


Novel Synthesis Strategy Speeds Up Identification of Simpler Versions of Natural Product


A new chemical synthesis strategy to harvest the rich information found in natural products has led to the identification of novel, simpler derivatives with potential to selectively protect neurons, important for neurodegenerative diseases like Alzheimer’s disease, or to prevent the body’s immune system from rejecting organ transplants, according to a Baylor University-led study.



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