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Taking the STING Out of MND

News   Oct 08, 2020 | Original story from the Walter and Eliza Hall Institute

 
Taking the STING Out of MND

Almost all patients with MND have evidence of TDP-43 (red) being in the wrong place inside motor neuron cells. Mitochondria (blue) provide power to motor neurons, but if invaded by TDP-43, they leak out their DNA (green) which triggers a virus sensor called STING. Drugs targeting STING prevent inflammation and keep MND patient motor neurons alive longer in laboratory tests. Credit: Image courtesy of the Walter and Eliza Hall Institute of Medical Research

 
 
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