Transplantation with induced neural stem cells improves stroke recovery in mice
News Oct 11, 2016
Results showed cells to be effective in promoting functional recovery and survival in mice modeled with stroke, and may even be protective when administered early -
In a study to determine whether induced neural stem cells (iNSCs), a type of somatic cell directly differentiated into neural stem cells, could exert therapeutic effects when transplanted into mice modeled with ischemic stroke, researchers found that the cells promoted survival and functional recovery. Additionally, they discovered that when administered during the acute phase of stroke, iNSCs protected the brain from ischemia-related damage.
In contrast to other studies that have induced somatic cells to become pluripotent stem cells (iPSCs), which can then be differentiated into neural cells, this study directly converted somatic cells into neural stem cells. Researchers concluded that in addition to iNSC transplantation improving survival rate, results also demonstrated reduced infarct volume in the brain and enhanced sensorimotor function in the mice modeled with stroke.
The study is to be published in Cell Transplantation.
"We observed multiple therapeutic effects when using these cells to treat stroke in mice," said Dr. Koji Abe, Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science. "The iNSCs did not produce any adverse responses in the animals, including tumor formation, which may suggest they are safer than regular iPSCs. Further studies are needed to confirm this cell type as a candidate for cell replacement therapy for stroke."
"Use of iNSCs may improve the efficacy of cell transplantation procedures for stroke since they are able to be derived directly from other cells without the need for extra steps," said Dr. Shinn-Zong (John) Lin, Tzu Chi Hospital, Hualien City, Taiwan. "This is highly desirable in stroke, which has a narrow window in which the brain is most responsive to treatment. Whether the therapeutic effects produced by iNSCs are attributable to cell replacement or to secreted factors (paracrine effects), this method may be promising for treating stroke early."
Note: Material may have been edited for length and content. For further information, please contact the cited source.
Cell Transplantation Center of Excellence for Aging and Brain Repair
Yamashita T et al. Novel therapeutic transplantation of induced neural stem cells for stroke. Cell Transplantation, Published Online September 20 2016. doi: 10.3727/096368916X692988
One of the most heavily watched and debated fictional portrayals of suicide in recent years was the Netflix series "13 Reasons Why,". Given the series' popularity and its potentially harmful effects, researchers conducted a study to more fully understand the effects of the show through a survey of U.S. young adults before and after the release of its second season.
Cringe-worthy mistakes and embarrassing blunders made today won’t seem so bad tomorrow. That is, unless you’re an insomniac, new research shows. The scientists asked participants to relive their most shameful experiences while making MRI scans of their brain activity. While good sleepers literally settled those experiences as neutralized memories, people with insomnia were not able to do so.READ MORE
Scientists report that functional olfactory receptors, the sensors that detect odors in the nose, are also present in human taste cells found on the tongue. The findings suggest that interactions between the senses of smell and taste, the primary components of food flavor, may begin on the tongue and not in the brain, as previously thought.