Treating depression in Parkinson's disease patients: New research
News Apr 22, 2014
A group of scientists from the University of Kentucky College of Medicine and the Sanders-Brown Center on Aging has found interesting new information in a study on depression and neuropsychological function in Parkinson's disease (PD).
Published in the journal Psychiatry Research, the study, which assessed cognitive function in depressed and non-depressed patients with PD, found that the dopamine replacement therapy commonly used to treat motor symptoms of Parkinson's disease was associated with a decline in cognitive performance among depressed Parkinson patients.
In contrast, non-depressed Parkinson patients' cognitive function improved on dopamine replacement therapy.
The study also found that mood in depressed Parkinson's patients was actually worse while on dopaminergic medications.
"This was a surprise," said Lee Blonder, Ph.D., the study's principal investigator. "It is the opposite of our original hypothesis that both groups of PD patients would improve in cognitive performance on dopaminergic medications, and that mood in the depressed PD group would also improve."
A cohort of 28 patients with PD -- 18 nondepressed and 10 depressed -- were given a baseline series of tests to assess cognitive function and the incidence and severity of depression. They were then re-tested with and without their dopamine replacement therapy.
Results revealed a statistically signi?cant interaction between depression and medication status on three measures of verbal memory and a facial affect naming task. In all cases, depressed Parkinson's patients performed signi?cantly more poorly while on dopaminergic medication than while off. The opposite pattern emerged for the non-depressed Parkinson's group.
Depression is a common and serious co-morbidity in patients with Parkinson's; studies suggest that approximately 40 percent of PD patients suffer from depression.
Blonder cautions that these results are to some extent preliminary due to the small cohort of 28 participants. "Additional studies are required before these results should be used to alter treatment plans," Blonder says. But, "future research should ultimately focus on investigating treatment options for patients with Parkinson's and depression to maximize patient function without compromising their mental health."
Note: Material may have been edited for length and content. For further information, please contact the cited source.
Lee X. Blonder, John T. Slevin, Richard J. Kryscio, Catherine A. Martin, Anders H. Andersen, Charles D. Smith, Frederick A. Schmitt. Dopaminergic modulation of memory and affective processing in Parkinson depression. Psychiatry Research, Published Online July 8 2013. doi: 10.1016/j.psychres.2013.06.003
Abnormal Prion Protein Found in the Skin of Patients That Died of CJDNews
Scientists have detected abnormal prion protein in the skin of nearly two dozen people who died from Creutzfeldt-Jakob disease (CJD).READ MORE
Whole-Brain Map of Memory Circuits Constructed from Human DataNews
The work elucidates the way different regions of the brain communicate during cognitive processes like memory formation.READ MORE
Long-Term Negative Physical and Mental Health Effects Associated With Disordered EatingNews
Findings from large twin study show disordered eating among 24-year-old women and men was an indicator of higher body weight, larger waist circumference, and lower psychological well-being ten years later.READ MORE