What drives an adolescent to abuse alcohol?
News Jul 10, 2014
By looking at 40 different factors in a 14 year old teens, including brain structure and function, personality, life experiences and genetics, researchers can predict with 70% accuracy who will go on to develop binge drinking within the next two years. Impulsivity, hopelessness, sensation-seeking traits, lack of conscientiousness, and other variables such as life events and a family history of drug use contribute to the likelihood of binge drinking.
Whether or not the child had had a single drink at age 14 was a particularly powerful predictor, the researchers found. Slightly over 40% of North American 13 and 14 year olds have used alcohol, while 10% of Quebec high school students graduate from high school with substance use problems. The study was driven by the IMAGEN consortium, a European research project on risk taking behaviour in teenagers. Patricia Conrod of the University of Montreal and CHU Sainte-Justine Hospital Research Centre designed the original assessment battery and the participant recruitment strategy for the IMAGEN study. She also developed the brief personality scale that was shown to be highly predictive of drinking at 14 and 16 years of age. The first and senior authors of the research article are affiliated with the University of Vermont, University College Dublin, and Trinity College Dublin.
In total, 2,400 European 14 year olds participated in the IMAGEN study. In addition to providing information about their life events, their psychological profile and their substance use, the children underwent an MRI as they played a game (to measure their brains responses to rewards) and were shown angry faces (to measure their emotional reactivity.) The team found that the right middle and precentral gyri and bilateral superior front gyrus areas of the brain were most revealing of the likelihood of future binge drinking. Compared to others, at risk youth had reduced grey matter volume but increased activity in their superior frontal gyrus when receiving a reward. In the premotor cortex, they had more grey matter and greater activity when they failed to inhibit themselves. The MRI results helped validate the factors that the researchers identified as placing a child at risk.
Indeed, the findings do not suggest that binge drinking is hardwired but rather give professionals working with youth ways of finding people in need of help. “The personality dimensions that were shown to be highly predictive of behaviour were assessed using a scale that is currently being used in schools across Montreal to provide targeted prevention to youth at risk of substance misuse,” Conrod said. “Early alcohol use strongly predicts adult alcohol dependence, and every year we can delay alcohol use translates to a 10% decrease in the likelihood of alcoholism later. Outreach efforts that correctly target particularly at risk youth can therefore be of lifelong significance and importance to that person.”
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Robert Whelan, Richard Watts, Catherine A. Orr, Robert R. Althoff, Eric Artiges, Tobias Banaschewski, Gareth J. Barker, Arun L. W. Bokde, Christian Büchel, Fabiana M. Carvalho, Patricia J. Conrod, Herta Flor, Mira Fauth-Bühler, Vincent Frouin, Juergen Gallinat, Gabriela Gan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Claire Lawrence, Karl Mann, Jean-Luc Martinot, Frauke Nees, Nick Ortiz, Marie-Laure Paillère-Martinot, Tomas Paus, Zdenka Pausova, Marcella Rietschel, Trevor W. Robbins, Michael N. Smolka, Andreas Ströhle, Gunter Schumann, Hugh Garavan & the IMAGEN Consortium. Neuropsychosocial profiles of current and future adolescent alcohol misusers. Nature, Published Online July 2 2014. doi: 10.1038/nature13402
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