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Hyperactive Brain Cells May Be to Blame When Antidepressants Don't Work

News   Feb 01, 2019 | Original Press Release from the Salk Institute

When Neurons Get the Blues

When neurons get the blues. This artistic image shows neurons derived from pluripotent stem cells of antidepressant (SSRI) resistant depressed patients. SSRI-resistant patient neurons display hyperactivity in response to serotonin. The study reveals potential mechanism associated with SSRI-resistance in major depressive disorder (MDD). The image is modified from Figure 2c of Vadodaria et al., Molecular Psychiatry, 2019. Credit: Salk Institute



"Lack of Cleaning" in Brain Cells is Central to Alzheimer’s Disease


An international research team has created a better understanding of Alzheimer's. They have shown that the cleaning system of the brain cells, the so-called mitophagy, is very weakened in animals and humans with Alzheimer's. And when they improve the cleaning system in the animals, the Alzheimer's symptoms almost disappear.


Can Fear Memories Be Extinguished?


Researchers have discovered a DNA modification that enhances our ability to extinguish fear. The findings could help guide the development of new treatments for fear-related anxiety disorders.


Mapping Brain Circuits in Newborns May Aid Early Detection of Autism


A new map of newborn babies’ brains offers details of structure that will provide a new reference for researchers studying both typical brain development and neurological disorders. Using noninvasive, 20-minute magnetic resonance imaging scans, researchers have revealed some of the complex and precisely organized brain architecture that emerges as the brain reshapes itself during the third trimester of pregnancy.



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