2-DE Analysis of Breast Cancer Cell Lines MDA-1833 and MDA-4175 with Distinct Metastatic Organ-Specific Potentials and Comparison with Parental Cell Line MDA-MB-231
Abstract
Breast cancer has diverse metastatic behavior. Subpopulations of cells with enhanced metastatic abilities either to bone (1833) or to lung (4175) have been isolated by the group of J. Massague by in vivo selection of MDA-MB-231 cells [Minn et al., 2005, Nature 436, 518-524]. We performed the 2-DE analysis of the cell lines. We have found and identified 11 differentially expressed protein spots.
Breast cancer has diverse metastatic behavior. Subpopulations of cells with enhanced metastatic abilities either to bone (1833) or to lung (4175) have been isolated by the group of J. Massague by in vivo selection of MDA-MB-231 cells [Minn et al., 2005, Nature 436, 518-524]. We performed the 2-DE analysis of the cell lines. We have found and identified 11 differentially expressed protein spots.
