Investigating the Effects of Fructose Consumption and Inadequate Copper Intake on Nonalcoholic Fatty Liver Disease
Metabolomics is a viable method for identifying compounds associated with NAFLD. In this investigation, high-quality data facilitate the identification of key metabolites differentiating normal versus diseased species.
Extraction of Analytes of Toxicolgical Interest from Plasma with Enhanced Matrix Removal-Lipid Material
Extraction of Analytes of Toxicolgical Interest from Plasma with Enhanced Matrix Removal-Lipid (EMR-Lipid) Material.
A Tissue-based Proteomic Study of VEGFR2 in Human Term Placentas
VEGFR2 is the main regulator of placental angiogenesis and at term is localized in endothelial cells (EC) of the villous vasculature. VEGFR2 immunoprecipitation (IP) of membrane proteins, extracted from the fetal compartment, isolated 30 proteins that were identified by proteomic analysis.
Automating Mass Spectrometry-Based Quantitative Glycomics using Tandem Mass Tag (TMT) Reagents with SimGlycan
One of the emerging trends in glycomics research is the innovation related to accurate MS based quantitative analysis of glycans.
RAMclust/RAMsearch: efficient post-XCMS feature clustering and annotation of MS-based metabolomics datasets
Chromatographically coupled mass spectrometry is a powerful tool for profiling, semi-quantitatively or quantitatively, a breadth of small molecules with sensitivity and selectivity.
Functional Analysis of RAD51B and RAD23B SNPs using Circular Chromosome Conformation Capture (4C) in Human Prostate Cell Lines
The aim of this study is to understand the mechanism behind the association between single nucleotide polymorphisms (SNPs), lying in non-coding regions near or within RAD51B and RAD23B, and prostate cancer risk by analysing their interactions with the whole genome using Circular Chromosome Conformation Capture (4C).
A Novel Benchtop Time-of-Flight GC-MS System for High Performance Analysis of Human Urine
A workflow was developed and implemented for the effective comparison of urine. It involved the preparation of stable compounds through derivatization, data acquisition using a high performance benchtop TOFMS, comprehensive data processing (NonTarget Deconvolution™), and quick retrospective analysis of rich datasets using Target Analyte Finding.
Platform Agnostic Data Processing Routine for Targeted and Untargeted Metabolite Identification in Drug Discovery
A discussion of a new informatics solution that addresses common challenges in metabolite identification and characterization--from LC/MS data processing and metabolites prediction to reporting and databasing of assembled biotransformation knowledge.
Molecular Abnormalities in Schizophrenia: Neurotransmission, Oxidative Stress, and Apoptosis
A multi-platform approach was employed to analyse distinct brain regions implicated in schizophrenia.
Resistance-Associated Variants in HCV Genotype 1 Populations
In this study we specifically investigated RAVs emerging in HCV genotype 1.