A Novel Benchtop Time-of-Flight GC-MS System for High Performance Analysis of Human Urine
Poster Sep 13, 2016
David E. Alonso, Joseph E. Binkley, Lorne M. Fell
The development of improved profiling workflows are critical for effective investigation of environmental exposure and its relationship to chronic diseases. Metabolomic methods are particularly useful in this endeavor due to the proximity of metabolites to system phenotype, and their relatively quick insight into system perturbations from diet, drugs, gut microbiota, etc. (Figure 1). Unfortunately, a major problem with these methods continues to be incomplete sample characterization due to metabolite diversity, wide concentration range, and the overall complexity of biological matrices.
Urine is an ideal bio-fluid for studying the effects of exposure, since it is easy to obtain in large volumes, and is relatively free from interfering proteins and lipids. In addition, high concentrations of drugs and other xenobiotic materials can be detected over extended periods of time. In this study, we used a high performance, benchtop gas chromatography time-of-flight mass spectrometer for comprehensive characterization of derivatized urine samples (Figure 2).
A New Tool for the Automated Sample Preparation of Whole Blood Samples by LC-MS using a Commercial AutosamplerPoster
Automated sample preparation reduces the costs per sample and minimizes sample handling errors. Usually expensive and highly specialized pipetting robots are used. However, most of these systems are not designed with a direct interface for LC-MS applications. In addition common pipetting systems are not optimized for smaller scale sample series. Here we present a new tool for liquid handling of whole blood samples and direct sample injection.
Multi-Residue Pesticide Analysis in Food Matrices Using Ultivo Triple Quad LC/MSPoster
Regulatory agencies have set maximum residue levels for hundreds of pesticides and their metabolites in foods.READ MORE
Analysis of Mycotoxins in Food Matrices using the Innovative Ultivo Triple Quad LC/MSPoster
A study demonstrating the accuracy and sensitive quantification of up to 12 regulated mycotoxin compounds in three commonly regulated foods.READ MORE
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