Acoustic Startle Response as a Prognostic Tool for Traumatic Brain Injury
Poster Feb 13, 2017
M. Grant Liska, Vivian A. Guedes, Connor Stonesifer, Lindsey Gelineau, Marci Crowley, David J. Eve, Cesar V. Borlongan*
Traumatic Brain Injury (TBI) is a leading cause of death and disability in military and civilian populations. TBI can occur from a number of insults - such as blunt force, blast impact, or penetrating wounds - all associated with acute cognitive and sensory symptoms. The Acoustic Startle Reflex (ASR) is a brain-stem mediated, tri-synaptic response to acoustic stimuli involving involuntary contraction of major muscle groups. Previous studies have demonstrated that this response is suppressed following the fluid-percussion model of traumatic brain injury (TBI). The possibility exists that the suppression of this response could be exploited for prognostic purposes.
Early life stress (ELS) is highly associated with development of psychopathology
and mood disorders in adulthood. Genetic studies have identified variation in the gene calcium voltage-gated channel subunit alpha1C (CACNA1C) to increase risk for several psychiatric disorders. This poster assessed the expression of Cacna1c following prepubertal stress.