Depression, Anxiety and Apathy in Young-Onset and Atypical Dementia: A systematic review
Poster May 25, 2018
Credit: Collins et al. UCL
Jessica D, Collins, Susie M.D. Henley, Aida Suarez-Gonzalez
Depression, anxiety and apathy are among the most frequent neuropsychiatric symptoms (NS) in typical Alzheimer’s disease, and impact quality of life, risk of institutionalisation, and caregiver burden. However, prevalence in atypical and young-onset phenotypes remains unknown.
This study aims to examine the body of empirical studies investigating the prevalence of depression, anxiety, and apathy in atypical and young-onset dementia.
Early life stress (ELS) is highly associated with development of psychopathology
and mood disorders in adulthood. Genetic studies have identified variation in the gene calcium voltage-gated channel subunit alpha1C (CACNA1C) to increase risk for several psychiatric disorders. This poster assessed the expression of Cacna1c following prepubertal stress.
We found a distinct subpopulation of Tregs within BMSCs. Tregs and BMSCs in co-culture conferred neuroprotection that varied in a dose-dependent manner. Tregs minimized stem cell production of IL-6, a pro-inflammatory cytokine, and inhibited BMSC secretion of FGF-beta, a cytokine related to BMSC proliferation and differentiation. The ratio of Tregs found natively in BMSCs is optimally adapted to provide the maximum neuroprotective benefit of stem cell treatment after ischemic stroke.READ MORE
This study found that coffee solutions treated at 5% are toxic to neurons. However, the toxicity reduced significantly at 2.5%. While the toxicity was significantly less allowing for more cells to survive at 2.5%, the levels of toxic amyloid beta 1-42 significantly reduced. This reduction in amyloid beta is associated with improvement in cognitive performance, as the presence of these toxic peptides is one of the characteristics of AD pathophysiology.READ MORE